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TANG Jinglong WANG Shuo LIU Li WANG Jian YUAN Fuqiang XI Tingfei

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- Journal of Radiation Research and Radiation Processing Vol. 31, Issue 2, Pages: 7-020301(2013)
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  1. （中国食品药品检定研究院医疗器械标准管理研究所医疗器械检定所）,北京,100050
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TANG Jinglong WANG Shuo LIU Li WANG Jian YUAN Fuqiang XI Tingfei. [J]. Journal of Radiation Research and Radiation Processing 31(2):7-020301(2013)
DOI：

TANG Jinglong WANG Shuo LIU Li WANG Jian YUAN Fuqiang XI Tingfei. [J]. Journal of Radiation Research and Radiation Processing 31(2):7-020301(2013) DOI：

摘要

研究了纳米羟基磷灰石（nano-HAP）颗粒肌肉注射后在小鼠体内的分布、蓄积和排泄，以了解nano-HAP是否具有体内迁移特性。试验分为nano-HAP和micro-HAP两组，分别将中子活化的nano-HAP和作为对照的微米羟基磷灰石（micro-HAP）经肌肉注射到小鼠体内，剂量为91 mg/kg。在1周、2周、4周、8周、12周、18周、24周时断髓处死动物，解剖并收集动物的血液、脑、心、肝、脾、肺、肾、胃、小肠、胸骨、子宫或睾丸、粪便和尿液。用高氯酸和双氧水将收集的样品消解后，通过液体闪烁计数器测定各脏器组织和排泄物中的45Ca ?射线计数来反映nano-HAP和micro-HAP在动物体内的分布。结果显示，肌肉注射nano-HAP后，大部分组织中45Ca ?射线计数范围为0－79 Counts×min-1×mg-1，注射micro-HAP后为0.0－25 Counts×min-1×mg-1。两种HAP颗粒在体内分布部位没有显著差异，说明nano-HAP颗粒不会以颗粒形态在体内迁移，不具有在体内迁移的生物特性。骨骼是nano-HAP和micro-HAP唯一的蓄积器官，整个试验期间，两组动物骨骼中的45Ca ?射线计数变化不大，但nano-HAP组骨骼中的45Ca ?射线计数显著高于micro-HAP组。这说明nano-HAP具有比micro-HAP更好的骨结合和骨诱导性。

Abstract

The present study was designed to investigate the distribution, accumulation and excretion of hydroxylapatite nanoparticles (nano-HAP)in mice with intramuscular administration. Mice were injected at 91 mg/kg with either nano-HAP or hydroxylapatite microparticles (micro-HAP) activated by neutrons, and then sacrificed at 1, 2 , 4 , 8, 12, 18, 24 week for getting samples, respectively. The main organs of the experimental animals were harvested for digestion, and then the counts of 45Ca in every sample were measured by a liquid scintillation counter. The results indicated that 0–79 counts×min-1×mg-1 45Ca could be detected in all main organs after nano-HAP injection and 0–25 counts×min-1×mg-1 after micro-HAP injection. There were no significant differences between the SNP group and SMP group (p>0.05) in the distribution in vivo. Bone is the only tissue for accumulation of nano-HAP and micro-HAP. Compared with micro-HAP, a larger amount of nano-HAP accumulated in bone. The results suggest that nano-HAP have a better osseointegration and bone inductivity.Cited

关键词

纳米羟基磷灰石颗粒体内分布中子活化小鼠

Keywords

Hydroxylapatite nanoparticleDistributionNeutron activationMice

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Distribution of hydroxylapatite nanoparticles injected via intravenous in mouse

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