Research status on p53 pathway-associated genes expression as radiation biodosimeter

ZHANG Deqin; LIU Qingjie

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Research status on p53 pathway-associated genes expression as radiation biodosimeter

更新时间：2023-03-27

- Research status on p53 pathway-associated genes expression as radiation biodosimeter
- Journal of Radiation Research and Radiation Processing Vol. 29, Issue 2, Pages: 65-69(2011)
- 作者机构：
  
  1.中国疾病预防控制中心辐射防护与核安全医学所　北京　100088
- 作者简介：
- 基金信息：
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ZHANG Deqin, LIU Qingjie. Research status on p53 pathway-associated genes expression as radiation biodosimeter. [J]. Journal of Radiation Research and Radiation Processing 29(2):65-69(2011)
DOI：

ZHANG Deqin, LIU Qingjie. Research status on p53 pathway-associated genes expression as radiation biodosimeter. [J]. Journal of Radiation Research and Radiation Processing 29(2):65-69(2011) DOI：

摘要

辐射生物剂量计在核事故受照人员剂量估算及辐射生物效应研究中具有重要的作用，被视为“金标准”的染色体畸变分析不能满足大批量快速检测的要求。因此，找到更为快速、简便的生物剂量计成为放射生物剂量学的研究热点。研究发现，电离辐射能够诱导转录调节网络中的基因表达发生变化，有希望成为辐射生物剂量计。涉及较多的是p53通路相关基因，其中包括mdm2、Cyclin G、CDKN1A、GADD45、PIG3、Fhl2、ISG20L1、PCNA、GDF15等。

Abstract

Radiation biodosimeter plays a vitally important role in estimating the absorbed doses of radiation victims and in the research on radiation biological effects. The "golden" biodosimeter, chromosome aberration analysis, is not suit for fast and high-throughout dose estimation. Developing a new fast and simple biodosimeter became the hotspot in radiation biodosimetry. Some studies showed that ionizing radiation could induce the gene expression changes (GEC) in the network of transcriptional regulation pathway, and GEC had the potential to be a biodosimeter. Many studies focused on p53 pathway-associated genes, including mdm2, Cyclin G, CDKN1A, GADD45, PIG3, Fhl2, ISG20L1, PCNA and GDF15.

关键词

辐射生物剂量计p53通路基因表达

Keywords

Radiation biodosimeterp53 pathwayGene expression

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National Institute for Radiation Protection, Chinese Center for Disease Control and Prevention

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