Radiosensitive effects and relative mechanism of CpG oligodeoxynuleotide

ZHANG Chao; WANG Jichao; CAI Jianming

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Radiosensitive effects and relative mechanism of CpG oligodeoxynuleotide

更新时间：2023-03-27

- Radiosensitive effects and relative mechanism of CpG oligodeoxynuleotide
- Journal of Radiation Research and Radiation Processing Vol. 29, Issue 5, Pages: 257-260(2011)
- 作者机构：
  
  1.第二军医大学海军医学系放射医学教研室　上海　200433
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ZHANG Chao, WANG Jichao, CAI Jianming. Radiosensitive effects and relative mechanism of CpG oligodeoxynuleotide. [J]. Journal of Radiation Research and Radiation Processing 29(5):257-260(2011)
DOI：

ZHANG Chao, WANG Jichao, CAI Jianming. Radiosensitive effects and relative mechanism of CpG oligodeoxynuleotide. [J]. Journal of Radiation Research and Radiation Processing 29(5):257-260(2011) DOI：

摘要

CpG-ODN是一组以非甲基化CpG为核心的寡核苷酸序列，能诱导脊椎动物产生先天性和获得性免疫应答。由于CpG-ODN具有免疫刺激作用，在疫苗佐剂、肿瘤治疗、过敏性疾病的免疫治疗等方面，表现出极强的使用价值和广阔的应用前景。本文主要就其在放射增敏方面的研究进展进行综述。

Abstract

Synthetic oligodeoxynucleotides (ODN) containing unmethylated deoxycytosine deoxyguanosine (CpG) motifs bind to Toll-like receptor 9 (TLR9) and can stimulate both innate and adaptive immune reactions. Therefore, CpG-ODN shows high worth and broad application prospects in clinic of adjuvants, immunotherapy for tumor and allergic diseases. The effect and relative mechanism of radiosensitive effects with CpG-ODN is discussed in this paper.

关键词

CpG-ODN肿瘤放射增敏

Keywords

CpG-ODNRadio-sensitizationTumor

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