EFFECT OF ALPHA-CALCIFEROL ON BONE MINERAL DENSITY, BONE HISTOMORPHOMETRY AND BONE BIOMECHANICS IN RATS BY RADIATIVE INJURY TO KIDNEY

ZHU Feipeng; WANG Hongfu; GAO Linfeng; JIN Weifang

您当前的位置：

首页 >

文章列表页 >

EFFECT OF ALPHA-CALCIFEROL ON BONE MINERAL DENSITY, BONE HISTOMORPHOMETRY AND BONE BIOMECHANICS IN RATS BY RADIATIVE INJURY TO KIDNEY

更新时间：2023-03-30

- EFFECT OF ALPHA-CALCIFEROL ON BONE MINERAL DENSITY, BONE HISTOMORPHOMETRY AND BONE BIOMECHANICS IN RATS BY RADIATIVE INJURY TO KIDNEY
- Journal of Radiation Research and Radiation Processing Vol. 21, Issue 3, Pages: 210-213(2003)
- 作者机构：
  
  1.复旦大学放射医学研究所骨代谢研究室　上海　200032
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
ZHU Feipeng, WANG Hongfu, GAO Linfeng, et al. EFFECT OF ALPHA-CALCIFEROL ON BONE MINERAL DENSITY, BONE HISTOMORPHOMETRY AND BONE BIOMECHANICS IN RATS BY RADIATIVE INJURY TO KIDNEY. [J]. Journal of Radiation Research and Radiation Processing 21(3):210-213(2003)
DOI：

ZHU Feipeng, WANG Hongfu, GAO Linfeng, et al. EFFECT OF ALPHA-CALCIFEROL ON BONE MINERAL DENSITY, BONE HISTOMORPHOMETRY AND BONE BIOMECHANICS IN RATS BY RADIATIVE INJURY TO KIDNEY. [J]. Journal of Radiation Research and Radiation Processing 21(3):210-213(2003) DOI：

摘要

观察了α骨化醇对肾辐射损伤骨质疏松大鼠骨密度、骨形态计量和骨生物力学的影响。6月龄健康雄性SD大鼠32只，随机分为4组，每组8只，分别是模型组（Model），假手术组（Sham），α骨化醇治疗组（Bone one），治疗对照组（Fosamax）。肾脏局部辐射制备骨质疏松模型，照射后1周开始给药，α骨化醇治疗组给予萌格旺0.1μg•kg,−1, BW.d，对照组给予福善美10mg•kg,−1, BW.d，药物用硝酸纤维素钠（CMC）制成混悬液，1mL/只，灌胃给予，连续3个月，动物颈动脉放血处死，收取L1−L4 腰椎及右侧股骨，分别测定骨密度、骨形态计量和生物力学指标。结果表明，α骨化醇治疗组与模型组比较，腰椎骨密度明显提高（,p,<,0.01），骨小梁体积、宽度显著增加，骨小梁间距变小（,p,<,0.05，,p,<,0.01），股骨、腰椎的最大载荷及最大应力明显增强（,p,<,0.05，,p,<,0.01）。α骨化醇对肾局部辐射诱导的骨质疏松模型大鼠的骨密度、骨形态计量和骨生物力学等指标有明显的改善作用。

Abstract

The work is to study the effects of alpha-calciferol on bone mineral density, histomorphometry and biomechanics in rats with osteoporosis induced by irradiation of the rat kidney. 32 male SDrats of six months in age were randomly divided into 4 groups ( 8 rats per group), i.e. the model group,the sham group, the bone one group and the fosamax group. Osteoporosis was developed in the rats by irradiating the kidney. Then the rats were administrated orally as follows in a 90 days, 0.1g•kg,-1, BW.d of alpha-calciferol for the bone one group, 10 mg•kg,-1, BW.d of alendronate sodium in 1mL CMC for the fosamax group, and 1mL CMC for both the model group and sham group. BMD of L1-4, bone gistomorphometry and the bone biomechanical properties were measured. Compared with the model group, both the bone one group and the fosamax group were characterized with sigmificantly higher BMD of L1-4 (,p,<,0.01), significantly larger volume and width of bone trabecula, smaller space of bone trabecula (,p,<,0.05,p,<,0.01), and significantly larger maximal stress of femur and lumbar vertebra (,p,<,0.05,p,<,0.01). It is concluded that Alphacalciferol can improve BMD, bone histomorphometry and bone biomechanical properties in rat osteoporosis induced by kidney irradiation.

关键词

辐射肾脏骨代谢α骨化醇

Keywords

RadiationKidneyBone metabolismAlpha-calciferol

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

EFFECTS OF 15Gy ¹³⁷Cs γ-RAYS RADIATION OF RAT KIDNEYS ON BONE METABOLISM

Mechanisms of bone metabolism abnormality in rats induced by γ-ray irradiation of the kidneys

Trends and levels of environmental radiation in Shenzhen from 2011 to 2020

Review of the synthesis of semiconductor nanomaterials using ionizing radiation technology

Bioinformatics analysis of differentially expressed genes in irradiated non-small cell lung cancer

Related Author

No data

Related Institution

Department of Bone Metabolism, Institute of Radiation Medicine, Fudan University

Institute of Radiation Medicine, Fudan University

Shanghai Municipal Center For Diseases Control And Prevention

Shenzhen Ecological and Environmental Monitoring Center of Guangdong Province

College of Chemistry and Chemical Engineering, Hunan Normal University

⁰