changes in brain development of rat fetus exposed to <sup>137</sup>Cs γ rays in different pregnant periods of the female rats

GUO Yuefeng; WANG Mingming

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changes in brain development of rat fetus exposed to ¹³⁷Cs γ rays in different pregnant periods of the female rats

更新时间：2023-03-30

- changes in brain development of rat fetus exposed to ¹³⁷Cs γ rays in different pregnant periods of the female rats
- Journal of Radiation Research and Radiation Processing Vol. 22, Issue 4, Pages: 234-236(2004)
- 作者机构：
  
  1.中国辐射防护研究院　太原　030006
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GUO Yuefeng, WANG Mingming. changes in brain development of rat fetus exposed to ¹³⁷Cs γ rays in different pregnant periods of the female rats. [J]. Journal of Radiation Research and Radiation Processing 22(4):234-236(2004)
DOI：

GUO Yuefeng, WANG Mingming. changes in brain development of rat fetus exposed to ¹³⁷Cs γ rays in different pregnant periods of the female rats. [J]. Journal of Radiation Research and Radiation Processing 22(4):234-236(2004) DOI：

摘要

用,137,Cs γ射线对孕期分别为第11天和第16天的雌性大鼠进行一次性全身照射，吸收剂量分别为0.2、0.4、0.9、2.0Gy，观察胚胎发育不同时期受,137,Cs γ射线照射后仔鼠条件饮水反应和大脑海马锥体细胞计数的变化。结果表明，不同孕期的孕鼠受,137,Cs γ射线照射均可导致仔鼠大脑海马锥体细胞计数和条件饮水反应达标率显著减少，两者的剂量效应关系均可表示为,Y,=a−blog,10,D,(,Y,为效应，,D,为剂量)；仔鼠的条件饮水反应达标率与其大脑锥体细胞计数显著相关，且孕期第11天受照射仔鼠的条件饮水反应达标率低于孕期第16天受照射的仔鼠。

Abstract

Pregnant rats in 11d and 16d of their pregnancy were given one−off whole body exposure by ,137,Cs γ rays to 0.2, 0.4, 0.9 and 2.0Gy, respectively. Changes were observed in conditioned drinking response and cerebrum hippocampi cone cell number of the baby rats exposed to the γ rays in different periods of their embryo development. As a result, that pregnant rats exposed to ,137,Cs γ rays in different pregnant periods may induce significant decrease in cerebrum hippocampi cone cell number and achieving rate of conditioned drinking response of the babies. The dose−response relationship can be described by ,Y, = a−b log,10,D,. The achieving rate of conditioned drinking response were significantly correlated to cerebrum hippocampi cone cell number in the babies, and the achieving rate of conditioned drinking response of the babies exposed at pregnant 11d was lower than others exposed at pregnant 16d.

关键词

孕期脑发育剂量效应关系

Keywords

Pregnant periodsBrain developmentDose−response relationship

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changes in brain development of rat fetus exposed to 137Cs γ rays in different pregnant periods of the female rats

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changes in brain development of rat fetus exposed to ¹³⁷Cs γ rays in different pregnant periods of the female rats