The studies of effect on tumor cell apoptosis with SOD and its anti−oxidation effect III. The effect of SOD on lipid peroxidation of tumor cell of tumor−bearing mice under fractional irradiation

LIU Yongbiao; ZHAO Jie; LIU Ying; HAO Xingzhi; WANG Xu; YAO Side

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The studies of effect on tumor cell apoptosis with SOD and its anti−oxidation effect III. The effect of SOD on lipid peroxidation of tumor cell of tumor−bearing mice under fractional irradiation

更新时间：2023-03-30

- The studies of effect on tumor cell apoptosis with SOD and its anti−oxidation effect III. The effect of SOD on lipid peroxidation of tumor cell of tumor−bearing mice under fractional irradiation
- Journal of Radiation Research and Radiation Processing Vol. 22, Issue 4, Pages: 243-248(2004)
- 作者机构：
  
  1.中国科学院上海应用物理研究所辐射技术应用中心　上海　201800
  2.徐州医学院肿瘤研究所　徐州　221002
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LIU Yongbiao, ZHAO Jie, LIU Ying, et al. The studies of effect on tumor cell apoptosis with SOD and its anti−oxidation effect III. The effect of SOD on lipid peroxidation of tumor cell of tumor−bearing mice under fractional irradiation. [J]. Journal of Radiation Research and Radiation Processing 22(4):243-248(2004)
DOI：

LIU Yongbiao, ZHAO Jie, LIU Ying, et al. The studies of effect on tumor cell apoptosis with SOD and its anti−oxidation effect III. The effect of SOD on lipid peroxidation of tumor cell of tumor−bearing mice under fractional irradiation. [J]. Journal of Radiation Research and Radiation Processing 22(4):243-248(2004) DOI：

摘要

以荷瘤小鼠为动物模型，研究了全身照射下注射超氧化物歧化酶（SOD）对肿瘤细胞脂质过氧化、肿瘤组织端粒酶活性、肿瘤原癌基因c−Jun蛋白表达的影响。研究发现， SOD能增加S,180,肉瘤及Lewis肺癌组氧化产物丙二醛（MDA）含量，降低S,180,肉瘤谷胱甘肽（GSH）含量及血清超氧化物歧化酶总活力（T−SOD）、匀浆谷胱甘肽过氧化物酶（GPX−Px）活力；降低Lewis肺癌组GPX−Px及T−SOD活力，不影响GSH含量；降低H,22,肝癌组GPX−Px的活力，不影响MDA、GSH含量及T−SOD活力。SOD明显降低接受电离辐射的S,180,肉瘤及H,22,肝癌荷瘤小鼠肿瘤组织中端粒酶的阳性表达率，减少原癌基因c−Jun蛋白在S,180,肉瘤、Lewis肺癌荷瘤鼠中的表达。这一辐射增敏作用因肿瘤的种类而不同，可能与SOD在不同肿瘤中对癌基因c−Jun蛋白表达和端粒酶活性影响及药物在不同器官的代谢差异有关。

Abstract

In this paper the effect of injury of SOD on lipid peroxidation of tumor cell, telomerase activities in tumor tissues, expression of protooncogene c−Jun pretein were been studied with irradiated tumor−bearing mice. It has been found that content of MDA increased in S,180 , sarcom group and Lewis lung cancer group in situation of SOD injury while the content of GSH, GPX and activity of T−SOD decreased For former and with no change of GSH for later. It has also been found that SOD can reduce the telomerase activities in S,180, and H,22, and expression of protooncogene c−Jun in S,180, sarcom, Lewis lung cancer tumor tissues. The radiosensitivity of SOD may have some relationship with the effect on expression of protooncogene c−Jun and telomerase activities, and metabolism of SOD in different kinds of tumor.

关键词

超氧化物歧化酶荷瘤小鼠辐射敏感性原癌基因c−Jun端粒酶

Keywords

Superoxide dismutaseTumor−bearing miceRadiosensitivityRotooncogene c−JunTelomerase

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