Protection effect of ginkgo albumin extract on γ-ray irradiated mice
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Protection effect of ginkgo albumin extract on γ-ray irradiated mice
Journal of Radiation Research and Radiation ProcessingVol. 23, Issue 6, Pages: 359-365(2005)
作者机构:
1.华中农业大学食品科技学院天然产物化学教研室 武汉 430070
2.湖南科技学院化学生物系 永州 425006
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DENG Qianchun, CHEN Chunyan, DUAN Huike, et al. Protection effect of ginkgo albumin extract on γ-ray irradiated mice. [J]. Journal of Radiation Research and Radiation Processing 23(6):359-365(2005)
DOI:
DENG Qianchun, CHEN Chunyan, DUAN Huike, et al. Protection effect of ginkgo albumin extract on γ-ray irradiated mice. [J]. Journal of Radiation Research and Radiation Processing 23(6):359-365(2005)DOI:
Protection effect of ginkgo albumin extract on γ-ray irradiated mice
白果清蛋白提取物(,Ginkgo, albumin extract,GAE)是本实验室首次从白果中分离提取得到的具有较好抗氧化及延缓衰老活性的水溶性蛋白提取物,本工作探讨了白果清蛋白提取物对8.5Gy及3.2Gy的γ射线辐射损伤小鼠的保护作用。实验结果表明,8.5Gy的γ射线辐射小鼠后,其30d存活率呈显著性下降,辐射对照组的存活率为0,GAE高剂量给药组为20%;外周血象在辐射后受到不同程度的破坏,与辐射对照组相比,GAE给药组的血象指标下降幅度较小,恢复较快,具有显著性的差异;GAE能显著增加中剂量的γ射线辐射损伤小鼠血清中超氧化物歧化酶(Superoxide dismutase,SOD)的活性和DNA含量,显著性促进辐射小鼠体内受损免疫机能的恢复。结果表明,GAE能通过增强辐射损伤小鼠的抗氧化能力、造血功能及体内免疫功能来起到对辐射损伤小鼠的保护作用。
Abstract
Water soluble ginkgo albumin extract (GAE), which was extracted for the first time from seeds of ,Ginkgo bilbo L, in our laboratory. has good antioxidant and anti-aging activity. In this paper, protective effect of GAE on γ−rays irradiated mice was studied. The results showed that the mice irradiated to 8.5Gy was zero, whereas survival rate of the high dosage GAE group was 20 percent. Blood picture of the 8.5Gy irradiated mice suffered damages of different degrees, while blood picture index of the GAE group decreased slower and recovered faster significantly than the irradiation control group. GAE and Vitamin C could significantly enhance serum SOD activity in serum and increase DNA content in bone marrow cells, and also promote recovery of damaged immunology function of the irradiated mice. These suggest that GAE may protect mice from the radiation damages by enhancement of antioxidant activity, hemopoiesis function and immunologic function of mices.
关键词
白果清蛋白提取物γ射线辐射免疫功能抗氧化能力造血功能保护作用
Keywords
Ginkgo Albumin Extractγ−ray irradiationAntioxidant activityHemopoiesis functionImmunologic functionProtect effect