Kinetic study for enzymatic degradation of PCL

ZHANG Longbin; ZHU Guangming; XU Shuogui; WANG Jinhua; QIN Ruifeng

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Kinetic study for enzymatic degradation of PCL

更新时间：2023-03-30

- Kinetic study for enzymatic degradation of PCL
- Journal of Radiation Research and Radiation Processing Vol. 24, Issue 5, Pages: 275-278(2006)
- 作者机构：
  
  1.西北工业大学应用化学系　西安710072
  2.第二炮兵工程学院　西安710025
  3.第二军医大学长海医院　上海200433
- 作者简介：
- 基金信息：
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ZHANG Longbin, ZHU Guangming, XU Shuogui, et al. Kinetic study for enzymatic degradation of PCL. [J]. Journal of Radiation Research and Radiation Processing 24(5):275-278(2006)
DOI：

ZHANG Longbin, ZHU Guangming, XU Shuogui, et al. Kinetic study for enzymatic degradation of PCL. [J]. Journal of Radiation Research and Radiation Processing 24(5):275-278(2006) DOI：

摘要

研究了聚己内酯（Polycaprolactone, PCL）和辐射交联PCL的脂肪酶降解行为及酶促反应动力学，得到了PCL降解速度与时间和底物浓度的关系及Michaelis-Menten 常数。实验发现，降解产物浓度随着降解时间和底物浓度增加而增加。PCL粉末和交联PCL颗粒的降解动力学较好地符合米氏方程，其动力学参数,K,m,分别为1.14、71.95mg/mL，最大降解速度,V,max,分别为0.39、0.96mL/h。

Abstract

Kinetics of enzymatic degradation behavior of cross-linked PCL was studied. It is well known that the enzymatic hydrolysis of water-insoluble PCL by depolymerases produces water-soluble products. The result showed that the concentration of product in the solution increased with the time and substrates concentration. The degradation kinetics followed Mechaelis-Menten equation. The degradation parameter of the PCL powder was 1.14mg/mL for ,K,m, and 0.39mL/h for ,V,max, respectively. And the degradation parameter of cross-linked PCL particulate was 71.95mg/mL for ,K,m, and 0.96mL/h for ,V,max, respectively.

关键词

聚己内酯辐射交联酶降解动力学

Keywords

PolycaprolactoneEnzymatic degradationKineticsTitrimetry

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Department of Applied Chemistry, Northwestern Polytechnic University, West Friendship Road

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