Bio-effect of modified multi-wall carbon nanotubes on <italic style="font-style: italic">Tetrahymena pyriformis</italic>

GUO Jinxue; XIN Xueqiong; ZHU Ying; LI Wenxin

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Bio-effect of modified multi-wall carbon nanotubes on Tetrahymena pyriformis

更新时间：2023-03-30

- Bio-effect of modified multi-wall carbon nanotubes on Tetrahymena pyriformis
- Journal of Radiation Research and Radiation Processing Vol. 25, Issue 6, Pages: 326-329(2007)
- 作者机构：
  
  1.青岛科技大学化学与分子工程学院　青岛　266042
  2.中国科学院上海应用物理研究所　上海　201800
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GUO Jinxue, XIN Xueqiong, ZHU Ying, et al. Bio-effect of modified multi-wall carbon nanotubes on Tetrahymena pyriformis. [J]. Journal of Radiation Research and Radiation Processing 25(6):326-329(2007)
DOI：

GUO Jinxue, XIN Xueqiong, ZHU Ying, et al. Bio-effect of modified multi-wall carbon nanotubes on Tetrahymena pyriformis. [J]. Journal of Radiation Research and Radiation Processing 25(6):326-329(2007) DOI：

摘要

利用癸胺和葡萄糖胺对吸收γ光子后的多壁碳纳米管进行化学修饰，得到表面修饰了不同浓度官能团的碳纳米管，这些碳纳米管能够分别溶解于有机溶剂和水。研究了功能化后的多壁碳纳米管对四膜虫(,Tetrahymena pyriformis,) 的生物效应。结果显示，表面修饰了癸胺的碳纳米管对四膜虫的生长具有明显的抑制作用，而表面修饰了葡萄糖胺的碳纳米管则能够促进四膜虫的生长。进一步研究发现，γ光子通过提高碳纳米管表面修饰官能团的量，强化了它们对于四膜虫的生物效应。本工作在研究碳纳米管对单细胞生物所引起的生物效应方面做出了有益探索，并且为碳纳米管生物医药领域的应用提供了新思路。

Abstract

Multi-walled carbon nanotubes (MWNTs) irradiated with γ-rays were chemically modifified with glucosamine and decylamine, respectively. The cytotoxicity of ,Tetrahymena pyriformis, exposured to irradiated MWNTs, MWNTs modifyed with glucosamine and decylamine (denoted by G-MWNTs and D-MWNTs) was carried out. The results indicated that MWNTs modified with different functional groups exhibited different bioactivity to ,Tetrahymena pyriformis,. D-MWNTs showed a significant toxicity to ,Tetrahymena pyriformis, and the viability of cells reduced to 46.2%. And G-MWNTs promoted significantly the growth of cells, with the viability being up to 308%. More interestingly, it was shown that the toxicity and bioactivity of modified MWNTs to cells was changed along with the contents of functional groups bound on the surface of MWNTs. The studies may supply a possible strategy for enhancing or reducing the toxicity of MWNTs to meet certain applications in biological and medical field.

关键词

多壁碳纳米管γ射线化学修饰细胞毒性四膜虫

Keywords

Multi-walled carbon nanotubes (MWNTs)γ-raysModificationToxicityTetrahymena pyriformis

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National Synchrotron Radiation Laboratory, University of Science and Technology of China

School of Nuclear Science and Technology, University of Science and Technology of China

Department of Radiation Medicine, School of Public Health, University of South China

Department of Physiology, Medical College, University of South China

Clinical Anatomy & Reproductive Medicine Application Institute, Medical College, University of South China

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Bio-effect of modified multi-wall carbon nanotubes on Tetrahymena pyriformis

DOI：

摘要

Abstract

关键词

Keywords

references