Screening on the high yield validamycin producing strain by implantationwith N<sup>+</sup> and Ti<sup>+</sup> ion sources

YU Long; AN Xiao

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Screening on the high yield validamycin producing strain by implantationwith N⁺ and Ti⁺ ion sources

更新时间：2023-03-30

- Screening on the high yield validamycin producing strain by implantationwith N⁺ and Ti⁺ ion sources
- Journal of Radiation Research and Radiation Processing Vol. 25, Issue 6, Pages: 371-374(2007)
- 作者机构：
  
  1.南京工业大学制药与生命科学学院　南京　210009
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YU Long, AN Xiao. Screening on the high yield validamycin producing strain by implantationwith N⁺ and Ti⁺ ion sources. [J]. Journal of Radiation Research and Radiation Processing 25(6):371-374(2007)
DOI：

YU Long, AN Xiao. Screening on the high yield validamycin producing strain by implantationwith N⁺ and Ti⁺ ion sources. [J]. Journal of Radiation Research and Radiation Processing 25(6):371-374(2007) DOI：

摘要

利用N,+,和Ti,+,离子注入对井冈霉素生产菌株进行诱变选育，比较了出发菌株经过两种离子源注入后的诱变效应。初步探索使用金属离子和气体离子交替注入诱变方法，得到了较高的正突变率和突变增幅。用该方法诱变得到一株高产菌株B1-3，其产井冈霉素A组分的效价为21514，比出发菌株提高54.4%。经多次传代实验表明该菌株的遗传稳定性较好。

Abstract

In order to compared the mutagenic effects of the validamycin producing the strain (,Streptomyces hygroscupicus, var. ,Jingganggensis, Yen.) was implanted with two kinds of ion sources. The results showed that when two kinds of ion sources implanted into the strain by turns, more positive mutants and higher yield would be acquired. Using this method, a high-yielding strain B1-3 was obtained, which produce the titer of validamycin A of 21514, and was 54.4% higher than that of the original strain.

关键词

离子注入诱变选育井冈霉素

Keywords

Ion implantationMutationValidamycinJinggangmycin

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Screening on the high yield validamycin producing strain by implantationwith N+ and Ti+ ion sources

DOI：

摘要

Abstract

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Screening on the high yield validamycin producing strain by implantationwith N⁺ and Ti⁺ ion sources