The variation of D-loop in mitochondrial genome and the mutation induced by irradiation

LI Yuwen; LIU Qingjie

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The variation of D-loop in mitochondrial genome and the mutation induced by irradiation

更新时间：2023-03-30

- The variation of D-loop in mitochondrial genome and the mutation induced by irradiation
- Journal of Radiation Research and Radiation Processing Vol. 26, Issue 1, Pages: 1-4(2008)
- 作者机构：
  
  1.中国疾病预防控制中心辐射防护与核安全医学所　北京　100088
- 作者简介：
- 基金信息：
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LI Yuwen, LIU Qingjie. The variation of D-loop in mitochondrial genome and the mutation induced by irradiation. [J]. Journal of Radiation Research and Radiation Processing 26(1):1-4(2008)
DOI：

LI Yuwen, LIU Qingjie. The variation of D-loop in mitochondrial genome and the mutation induced by irradiation. [J]. Journal of Radiation Research and Radiation Processing 26(1):1-4(2008) DOI：

摘要

线粒体基因组D环区作为非编码区，控制着mtDNA的复制与转录，由于自身的结构和功能特点，极易发生变异。变异形式包括突变和多态性，这些变异在疾病的发生和发展过程中起着非常重要的作用。此外，本文还简要介绍了辐射诱导的D环区突变的研究现状及其前景。

Abstract

As the non-code region of mitochondrial genome, the displacement-loop region (D-loop) controls the replication and transcription of mtDNA, but it is easy to be altered. The variation, including mutation and polymorphism, plays an important role in disease. Finally, the status quo of radiation induced D-loop variation and its perspective were outlined.

关键词

线粒体基因组 D环区突变多态性辐射

Keywords

Mitochondrial D-loopMutationPolymorphismIrradiation

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