Effect of irradiation with <sup>12</sup>C<sup>6+</sup> ions on space memory of mouse brain

ZHOU Qingming; ZHANG Hong; LIU Yang; ZHAO Weiping; LONG Jing; LI Ning; WANG Yanling

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Effect of irradiation with ¹²C⁶⁺ ions on space memory of mouse brain

更新时间：2023-03-30

- Effect of irradiation with ¹²C⁶⁺ ions on space memory of mouse brain
- Journal of Radiation Research and Radiation Processing Vol. 26, Issue 1, Pages: 39-42(2008)
- 作者机构：
  
  1.中国科学院近代物理研究所　兰州　730000
  2.中国科学院研究生院　北京　100049
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ZHOU Qingming, ZHANG Hong, LIU Yang, et al. Effect of irradiation with ¹²C⁶⁺ ions on space memory of mouse brain. [J]. Journal of Radiation Research and Radiation Processing 26(1):39-42(2008)
DOI：

ZHOU Qingming, ZHANG Hong, LIU Yang, et al. Effect of irradiation with ¹²C⁶⁺ ions on space memory of mouse brain. [J]. Journal of Radiation Research and Radiation Processing 26(1):39-42(2008) DOI：

摘要

为了研究,12,C,6+,离子辐照昆明小鼠全脑对其空间记忆的影响，采用0、0.5、1和2Gy的,12,C,6+,离子束辐照昆明小鼠全脑，用八臂迷宫测试小鼠在迷宫中的觅食速度，以及其空间记忆的变化。结果发现，辐照使小鼠的觅食速度降低，但随着训练次数的增加，受辐照组与对照组的觅食速度都提高，到训练第17天，辐照组与对照组觅食能力基本相同；辐照使小鼠的空间记忆能力短期下降，但随着时间的增加，辐照组小鼠的空间记忆能力恢复到了对照水平。以上结果提示，在0～2Gy的碳离子辐照的剂量水平，辐照在短期内影响小鼠的记忆，在一定时间后，这种影响得到恢复。

Abstract

In order to investigate the effect of irradiation with ,12,C,6+, ions on the space memory of the Kunming mouse, the mouse brain was irradiated with ,12,C,6+, ions at low doses of 0, 0.5, 1 and 2.0Gy respectively. It was shown that the speed of looking for baits decreased with irradiation doses and then increased with the increment of the training times while the 8-arms radial maze was tested for determination of space memory. And the speed of looking for baits in irradiated and then trained groups recovered to the control level at 17,th, day after irradiation. It was also found that the space memory of the mice decreased along with the irradiation dose, but recovered to the control level at 20th day after irradiation. The data suggested that the irradiation of 0~2Gy ,12,C,6+, ions affected the mouse space memory in a short period of time, and then it could be recovered with time gradually after the irradiation by training.

关键词

碳离子辐射小鼠空间记忆

Keywords

12C6+ ions radiationMouseSpace memory

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Department of Histology and Embryology, Fourth Military Medical University

Department of Radiation Medicine, Fourth Military Medical University

Department of Dentistry and Clinical Medicine; Fourth Military Medical University

Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection

School of Radiation Medicine and Public Health, Suzhou University

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Effect of irradiation with 12C6+ ions on space memory of mouse brain

DOI：

摘要

Abstract

关键词

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Effect of irradiation with ¹²C⁶⁺ ions on space memory of mouse brain