Studies on the interaction of AQ derivatives with G-quadruplexes

LIU Yuxia; DU Fuqiang; LIN Weizhen; LI Wenxin; LIN Nianyun

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Studies on the interaction of AQ derivatives with G-quadruplexes

更新时间：2023-03-30

- Studies on the interaction of AQ derivatives with G-quadruplexes
- Journal of Radiation Research and Radiation Processing Vol. 26, Issue 2, Pages: 98-102(2008)
- 作者机构：
  
  1.中国科学院上海应用物理研究所　上海　201800
  2.中国科学院研究生院　北京　100049
- 作者简介：
- 基金信息：
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LIU Yuxia, DU Fuqiang, LIN Weizhen, et al. Studies on the interaction of AQ derivatives with G-quadruplexes. [J]. Journal of Radiation Research and Radiation Processing 26(2):98-102(2008)
DOI：

LIU Yuxia, DU Fuqiang, LIN Weizhen, et al. Studies on the interaction of AQ derivatives with G-quadruplexes. [J]. Journal of Radiation Research and Radiation Processing 26(2):98-102(2008) DOI：

摘要

应用紫外-可见分光光度法(Ultraviolet and visible spectrophotometry, UV-Vis)，圆二色谱法(Circular dichroism, CD)和聚丙烯酰胺凝胶电泳法(Polyacrylamide gel electrophoresis, PAGE)研究了在不同阳离子溶液中形成G-四联体的构型及其与蒽醌衍生物的相互作用方式。研究发现，不同取代基的蒽醌衍生物在溶液中与G-四联体有不同的相互作用方式及可能的光敏损伤机制，其中AQS2以嵌入的方式与G-四联体相结合而2,7-AQS2则是沟渠结合。

Abstract

The structure of G-quadruplexes formed in different cation solutions and the corresponding mode of interaction with AQ derivatives have been studied using Ultraviolet and visible spectrophotometry(UV-Vis), Circular dichroism(CD) and Polyacrylamide gel electrophoresis(PAGE). The results reveal that mono- and tetracation- substituted anthraquinone derivatives, AQS2 and 2,7-AQS2, bind to G-quadruplexes with different mode resulting in dissimilar photodamage mechanisms. The former appears to bind to G-quadruplexes through intercalation while the latter associates with a groove.

关键词

G-四联体AQS227-AQS2圆二色谱聚丙烯酰胺凝胶电泳

Keywords

G-quadruplexAQS22;7-AQS2Circular dichroismPolyacrylamide gel electrophoresis(PAGE)

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1(Wenzhou Medical University,,)

2(Jiading campus, Shanghai Institute of Applied Physics, Chinese Academy of Sciences,,)

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