Progress of research on activation function of NK cell exposed to low dose radiation in adoptive cellular immunotherapy

PAN Xiaosong; SHI Yujia; YAO Yimin; XU Hong; LIU Fenju

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Progress of research on activation function of NK cell exposed to low dose radiation in adoptive cellular immunotherapy

更新时间：2023-03-30

- Progress of research on activation function of NK cell exposed to low dose radiation in adoptive cellular immunotherapy
- Journal of Radiation Research and Radiation Processing Vol. 27, Issue 3, Pages: 129-132(2009)
- 作者机构：
  
  1.苏州大学医学部放射医学与公共卫生学院　苏州　215123
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PAN Xiaosong, SHI Yujia, YAO Yimin, et al. Progress of research on activation function of NK cell exposed to low dose radiation in adoptive cellular immunotherapy. [J]. Journal of Radiation Research and Radiation Processing 27(3):129-132(2009)
DOI：

PAN Xiaosong, SHI Yujia, YAO Yimin, et al. Progress of research on activation function of NK cell exposed to low dose radiation in adoptive cellular immunotherapy. [J]. Journal of Radiation Research and Radiation Processing 27(3):129-132(2009) DOI：

摘要

NK细胞是机体杀伤肿瘤的重要免疫细胞，低剂量辐射（LDR）可以增强NK细胞的增殖能力及生物活性，其机制可能与LDR后内源性谷胱甘肽的诱导作用、增强P38MAPK信号传导途径有关。NK细胞特别是A-NK细胞是过继性细胞免疫治疗良好的细胞来源，具有很好的治疗恶性肿瘤应用前景。

Abstract

Natural killer cells is an important immunological factor in killing malignant cells. Low dose radiation can enhance proliferation and biological activity of NK cell. The involvement of P38MAPK signal pathway and endogenous glutathione induced by LDR may be the probable mechanism. Natural killer cell, especially adherent natural killer cell, is the preferential choice for adoptive cellular immunotherapy, which has a remarkable foreground in malignancy therapy.

关键词

NK细胞低剂量辐射过继性细胞免疫治疗

Keywords

Natural killer cellLow dose radiation (LDR)Adoptive cellular immunotherapy (ACI)

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THE EFFECT OF LYSATE OF SPLEEN CELLS AFTER LOW DOSE RADIATION(LDR) ON NK ACTIVITY

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Institute of Space Medico-Engineeri ng

Department of Medical Radiobiology, School of Radiation Medicine and Public Health, Soochow University

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