Preparation and characterization of chitosan with low molecular weight and high degree of deacetylation

ZHANG Liuzhen; XU Yujie; LIU Min; WENG Wanwen; DING Wenxiu; YANG Zhanshan

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Preparation and characterization of chitosan with low molecular weight and high degree of deacetylation

更新时间：2023-03-30

- Preparation and characterization of chitosan with low molecular weight and high degree of deacetylation
- Journal of Radiation Research and Radiation Processing Vol. 27, Issue 3, Pages: 177-181(2009)
- 作者机构：
  
  1.苏州大学医学部放射医学与公共卫生学院　苏州　215123
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ZHANG Liuzhen, XU Yujie, LIU Min, et al. Preparation and characterization of chitosan with low molecular weight and high degree of deacetylation. [J]. Journal of Radiation Research and Radiation Processing 27(3):177-181(2009)
DOI：

ZHANG Liuzhen, XU Yujie, LIU Min, et al. Preparation and characterization of chitosan with low molecular weight and high degree of deacetylation. [J]. Journal of Radiation Research and Radiation Processing 27(3):177-181(2009) DOI：

摘要

本工作先用强碱洗脱法提高原料壳聚糖的脱乙酰度，再通过,60,Co γ辐射降解降低壳聚糖的分子量，并用线性电位滴定法测定经强碱洗脱法处理过的壳聚糖脱乙酰度的变化，用乌氏粘度计法测定经,60,Co γ辐射降解后的壳聚糖分子量的改变，并用傅立叶变换红外光谱（Fourier transform infrared spectrometer，FT-IR）对产物进行了表征分析。结果表明，强碱洗脱法能有效提高壳聚糖的脱乙酰度，,60,Coγ辐射降解法能迅速降低壳聚糖的分子量，获得的产物能够满足研制体内污染放射性核素的纳米型促排剂的要求。

Abstract

The elution with sodium hydroxide was used to increase deacetylation (DD) degree of chitosan and ,60,Co γ-irradiation was applied to decrease its molecular weight. The change of chitosan’s degree of deacetylation (DD) was determined by linear potentiometric titration, and the change of molecular weight was measured by Ubbelohde Viscometer. Fourier transform infrared spectrometer was utilized to characterize and analyze the products. The result indicates that sodium hydroxide elution could increase deacetylation (DD) degree of chitosan efficiently and ,60,Co γ-rays irradiation could decrease its molecular weight remarkably. The products may be satisfied with the preparation of new nano-chelating agents.

关键词

壳聚糖脱乙酰度分子量红外光谱

Keywords

ChitosanDegree of deacetylation (DD)Molecular weightIR

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