The effect of MgSO<sub>4</sub> on radiation-induced brain inflammatory reaction of SD rats in the early stage

ZHANG Wei; TU Yu; WANG Lili; ZHOU Juying

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The effect of MgSO₄ on radiation-induced brain inflammatory reaction of SD rats in the early stage

更新时间：2023-03-30

- The effect of MgSO₄ on radiation-induced brain inflammatory reaction of SD rats in the early stage
- Journal of Radiation Research and Radiation Processing Vol. 27, Issue 4, Pages: 234-238(2009)
- 作者机构：
  
  1.山东省职业卫生与职业病防治研究院　济南　250062
  2.苏州大学医学部放射医学与公共卫生学院　苏州　215123
  3.苏州大学附属第一医院肿瘤放疗科　苏州　215006
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ZHANG Wei, TU Yu, WANG Lili, et al. The effect of MgSO₄ on radiation-induced brain inflammatory reaction of SD rats in the early stage. [J]. Journal of Radiation Research and Radiation Processing 27(4):234-238(2009)
DOI：

ZHANG Wei, TU Yu, WANG Lili, et al. The effect of MgSO₄ on radiation-induced brain inflammatory reaction of SD rats in the early stage. [J]. Journal of Radiation Research and Radiation Processing 27(4):234-238(2009) DOI：

摘要

为探讨硫酸镁对放射性脑损伤炎症反应的作用，用20 Gy的电子线对SD大鼠进行全脑照射，在辐照后1、7和14 d采用酶联免疫吸附法测定脑组织细胞间黏附分子(Intercellular surface adhesion molecule-1, ICAM-1)含量、分光光度法测定髓过氧化物酶(Myeloperoxidase, MPO)活性，苏木精-伊红(Hematoxylin-eosin, HE) 染色法进行病理形态学观察。结果显示，放射性脑损伤大鼠脑组织中ICAM-1含量及MPO活性明显增加，引起放射性脑损伤继发性炎症反应；给予硫酸镁能显著降低放射性脑损伤大鼠的ICAM-1含量及MPO的活性，减轻炎性细胞浸润及脑组织损伤。早期给予硫酸镁可减轻放射性脑损伤大鼠脑组织的炎症效应，发挥细胞保护作用。

Abstract

In order to ivestigate the effect of magnesium sulfate (MgSO,4,) on the inflammatory reaction, the whole brain of SD rats were irradiated with a dose of 20 Gy so as to establish radiation-induced brain injury model. The expression of intercellular surface adhesion molecule-1(ICAM-1) was measured serially with enzyme linked immunosorbnent assay (ELISA) and the activity of myeloperoxidase(MPO) in brain tissue was measured by the absorption spectrometry at 1, 7, 14 days after irradiation. The expression of ICAM-1 and the activity of MPO in brain of rat irradiated with 20Gy increase markedly. MgSO,4, can singificantly down-regulation the expression of ICAM-1 and the activity of MPO of the irradiated rats, and reduce tissue cell denaturalization and inflammatory cell infiltrate observed by use of light-microscopy. MgSO,4, used in the early stage after irradiation could reduce the inflammatory reaction and protect brains from radiation injury.

关键词

硫酸镁电子线大鼠脑炎症反应ICAM-1

Keywords

Magnesium sulfateElectronRatsBrainInflammatory reactionICAM-1

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Shanghai Ocean University

Department of Protection Medicine, Naval Medical Research Institute, The Second Military Medical University

苏州大学医学部放射医学与防护学院

School of Radiation Medicine and Protection, Medical School of Soochow University

School of Radiation Medicine and Protection, Soochow University

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The effect of MgSO4 on radiation-induced brain inflammatory reaction of SD rats in the early stage

DOI：

摘要

Abstract

关键词

Keywords

references

The effect of MgSO₄ on radiation-induced brain inflammatory reaction of SD rats in the early stage