Effect of Quercetin on radiosensitivity of human Uterine Cervix Cancer HeLa cells

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Effect of Quercetin on radiosensitivity of human Uterine Cervix Cancer HeLa cells

更新时间：2023-03-30

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- Effect of Quercetin on radiosensitivity of human Uterine Cervix Cancer HeLa cells
- Journal of Radiation Research and Radiation Processing Vol. 27, Issue 4, Pages: 229-233(2009)
- 作者机构：
  
  1.苏州大学医学部放射医学与公共卫生学院　江苏省放射医学与防护重点实验室　苏州　215123
- 作者简介：
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LIANG Xiaofang, HONG Chengjiao, ZHANG Baoguo. Effect of Quercetin on radiosensitivity of human Uterine Cervix Cancer HeLa cells. [J]. Journal of Radiation Research and Radiation Processing 27(4):229-233(2009)
DOI：

LIANG Xiaofang, HONG Chengjiao, ZHANG Baoguo. Effect of Quercetin on radiosensitivity of human Uterine Cervix Cancer HeLa cells. [J]. Journal of Radiation Research and Radiation Processing 27(4):229-233(2009) DOI：

摘要

为观察槲皮素对人宫颈癌细胞HeLa增殖及其放射敏感性的影响，以人宫颈癌细胞株HeLa为研究对象，以MTT比色法和克隆形成实验检测槲皮素对HeLa细胞生长的抑制作用，并以克隆形成实验观察槲皮素对HeLa细胞株放射敏感性的影响。结果表明槲皮素能明显抑制人宫颈癌HeLa细胞增殖，存在剂量依赖和时间依赖性。克隆形成实验显示槲皮素对HeLa细胞的作用可分为两部分，一部分抑制HeLa细胞增殖，另一部分为诱导HeLa细胞死亡。克隆形成实验也显示槲皮素联合X射线照射能著显降低照射后HeLa细胞的存活率。本实验研究认为槲皮素具有放射增敏作用，为临床开展放射线联合槲皮素治疗肿瘤的研究提供了实验依据。

Abstract

In order to investigate the effects of Quercetin on radiosensitivity of human Uterine Cervix Cancer HeLa cells, MTT assay and clonogenic assay were performed to evaluate the cytotoxicity of Quercetin on the cells. Clonogenic assay was used to observe its effects on the radiosensitivity of the cells. MTT result shows that the inhibition of Quercetin on the cells is in the dose-dependent and time-dependent. And the clonogenic assay result shows that the effect of Quercetin on HeLa cells can be divided into two parts, one for the inhibition of HeLa cells and another for the induction of HeLa cell death. The other clonogenic assay result also shows Quercetin can decrease clonogenic survival rate of HeLa cells exposed to X rays. The study shows Quercetin might enhance the radiosensitivity of the HeLa cell line. And it may provide a useful evaluation to combination of ionizing radiation and Quercetin for cancer patients.

关键词

槲皮素细胞增殖放射敏感性Hela细胞

Keywords

QuercetinCell proliferationRadiosensitivityHeLa cell

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