In this paper, the application of the entropy weight TOPSIS method to optimal layout points in monitoring the Xinjiang radiation environment has been indroduced. With the help of SAS software, It has been found that the method is more ideal and feasible. The method can provide a reference for us to monitor radiation environment in the same regions further. As the method could bring great convenience and greatly reduce the inspecting work, it is very simple, flexible and effective for a comprehensive evaluation.