Preparation and properties of a drug sustained-release hydrogel film

YUE Ling; YANG Zhanshan; YANG Shuqin; LI Qinghua

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Preparation and properties of a drug sustained-release hydrogel film

更新时间：2023-03-30

- Preparation and properties of a drug sustained-release hydrogel film
- Journal of Radiation Research and Radiation Processing Vol. 27, Issue 5, Pages: 312-316(2009)
- 作者机构：
  
  1.苏州大学医学部放射医学与公共卫生学院　苏州　215123
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YUE Ling, YANG Zhanshan, YANG Shuqin, et al. Preparation and properties of a drug sustained-release hydrogel film. [J]. Journal of Radiation Research and Radiation Processing 27(5):312-316(2009)
DOI：

YUE Ling, YANG Zhanshan, YANG Shuqin, et al. Preparation and properties of a drug sustained-release hydrogel film. [J]. Journal of Radiation Research and Radiation Processing 27(5):312-316(2009) DOI：

摘要

研制一种能加速伤口愈合的水凝胶药物缓释膜。应用冷冻-解冻法制备了含（或不含）药物的水凝胶膜，研究其理化性能及药物体外释放规律；应用扩散法研究了冷冻-解冻过程对庆大霉素效价的影响。结果显示，冷冻4 h形成的水凝胶溶胀度为841.21%，凝胶分数、抗张强度和断裂伸长率分别为96.10%、0.222 MPa和673.50%；冷冻4 h的冻融过程对硫酸庆大霉素的效价无影响（,p,>,0.05）；掺加药物的水凝胶膜在6 h内药物快速释放达高峰，累计释放率为59.57%，而后缓慢释放，持续到第5天，其释放规律符合Higuchi方程，释药原理属骨架型扩散释放机制。结果表明，该法制备的水凝胶膜具有良好的理化性能和抗生素缓释功能。

Abstract

A hydrogel film of drug sustained-release was prepared to accelerate wound healing. The hydrogel films containing drug or not were prepared by the freezing and thawing process. Their properties such as the physicochemical property and the drug release behavior in vitro were studied. Effect of the freezing and thawing process on antimicrobial efficacy of the gentamicin was evaluated by diffusion method. The results indicate that swelling ratio of the hydrogel films freezed for 4h is 841.21% and their gel fraction, tensile strength and elongation at break is 96.10%, 0.222 MPa and 673.50% respectively. The antimicrobial efficacy of the gentamicin has no change. The hydrogel film contained gentamicin releases the antibiotic to peak during 6 h with the cumulative drug release rate of 59.57%. The drug releases continually up to the 5th day. The drug delivery conforms to Higuchi kinetic equation, and mechanism of the drug release is matrix diffusion. The results show that the hydrogel film prepared by the freezing and thawing process display satisfactory physicochemical properties and can be used as a drug delivery system.

关键词

水凝胶膜冷冻-解冻法缓释性能药物释放

Keywords

Hydrogel filmsFreezing-thawing processSustained release propertyDrug delivery

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