The irradiation damage of mice induced by internal tritium oxide

CUI Fengmei; HU Mingjiang; BAO Guangliang; SUN Liang; WANG Daojin; TONG Jian

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The irradiation damage of mice induced by internal tritium oxide

更新时间：2023-03-30

- The irradiation damage of mice induced by internal tritium oxide
- Journal of Radiation Research and Radiation Processing Vol. 27, Issue 5, Pages: 317-320(2009)
- 作者机构：
  
  1.苏州大学医学部放射医学与公共卫生学院　苏州　215123
  2.江苏省放射医学与防护重点实验室　苏州　215123
  3.中国科学院上海应用物理研究所　上海　201800
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CUI Fengmei, HU Mingjiang, BAO Guangliang, et al. The irradiation damage of mice induced by internal tritium oxide. [J]. Journal of Radiation Research and Radiation Processing 27(5):317-320(2009)
DOI：

CUI Fengmei, HU Mingjiang, BAO Guangliang, et al. The irradiation damage of mice induced by internal tritium oxide. [J]. Journal of Radiation Research and Radiation Processing 27(5):317-320(2009) DOI：

摘要

为探讨氚水染毒后小鼠外周血白细胞总数和骨髓嗜多染红细胞微核率的改变，小鼠腹腔注入不同初始量的氚水，2、4、6、10和28 d眼球摘除取血，处死后取两侧股骨，并计数外周血白细胞总数和骨髓嗜多染红细胞微核率。结果表明，随氚水初始注入量的增加，骨髓嗜多染红细胞微核率相应增高（,p,<,0.05），外周血白细胞总数相应降低，但只有初始注入量为16.65×10,5,Bq/g的剂量组差异有统计学意义。氚水初始注入量相同时，随注入后时间延长，骨髓嗜多染红细胞微核率持续增加，外周血白细胞总数第2天至第6天持续下降（,p,<,0.05），第10 天后已恢复。表明外周血白细胞和骨髓嗜多染红细胞微核，可作为氚水染毒后的早期辐射损伤指标。

Abstract

To study the internal radiation effects of tritiated water on the amount of cells of peripheral white blood cell (WBC) and micronucleus rate of polychromatic erythrocytes (MNPCE) in mice, C57BL/6J mice were randomly divided into several groups: one control group, two groups with injection of different initial concentration of T,2,O, and five groups with injection of same initial concentration of T,2,O, but different time for sacrifice (i.e. the 2nd, 4th, 6th, 10th and 28th day after injection). The amount of peripheral WBC and MNPCE were measured. In different initial concentration groups, the MNPCE in bone marrow increases (,p,<,0.05) with increment of cumulative doses. The amount of peripheral WBC of the group with initial concentration of 16.65×10,5,Bq/g is higher than that of the other groups. In the same initial concentration groups, the total number of peripheral WBC decreases (,p,<,0.05) before the 6th day and recovers at the 10th day after injection. The MNPCE increases continuously to the 28th day after injection. The amount of peripheral WBC and the MNPCE in bone marrow can be used as early sensitive indicators for internal exposure to tritium irradiation.

关键词

氚水小鼠外周血白细胞嗜多染红细胞微核

Keywords

Tritium oxideMousePeripheral white blood cellPolychromatic erythrocytesMicronuclei

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