Microwave-assisted organic synthesis, as a novel 'green’ synthesis technology, has been given more and more attention. It has been widely applied in many unit reactions, such as esterification, condensation, oxidation and reduction reaction etc. The unique and high efficiency heating effect of microwave, in many cases, could increase the reaction rate and product selectivity. Even some reactions could be taken place successfully in microwave while it was almost impossible in conventional heating. In this paper, recent progresses in the applications of microwave technique in fluorination reaction are reviewed. In addition, the problems during the course of industrialization are also discussed.