Recent progress of applying mesenchymal stem cells in therapy of urgent radiation damage

LIU Jiangong; GUO Wanlong; ZHANG Shuxian; DUAN Zhikai

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Recent progress of applying mesenchymal stem cells in therapy of urgent radiation damage

更新时间：2023-03-30

- Recent progress of applying mesenchymal stem cells in therapy of urgent radiation damage
- Journal of Radiation Research and Radiation Processing Vol. 28, Issue 3, Pages: 134-137(2010)
- 作者机构：
  
  1.中国辐射防护研究院放射医学与环境医学研究所　太原　030006
- 作者简介：
- 基金信息：
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LIU Jiangong, GUO Wanlong, ZHANG Shuxian, et al. Recent progress of applying mesenchymal stem cells in therapy of urgent radiation damage. [J]. Journal of Radiation Research and Radiation Processing 28(3):134-137(2010)
DOI：

LIU Jiangong, GUO Wanlong, ZHANG Shuxian, et al. Recent progress of applying mesenchymal stem cells in therapy of urgent radiation damage. [J]. Journal of Radiation Research and Radiation Processing 28(3):134-137(2010) DOI：

摘要

目前对于急性放射病的治疗，细胞因子治疗仍是一种主要的手段。造血干细胞移植配型比较困难，严重的移植抗宿主病（Graft versus host disease, GVHD）迫使人们寻找新的行之有效的方法。间充质干细胞(Mesenchymal stem cells, MSC)具有分泌造血生长因子、重建造血微环境、低免疫原性、易于外源基因转染和表达等优点，将其应用于急性辐射损伤的临床治疗具有十分广阔的前景。本文就MSC的生物学特性以及其在辐射损伤中的作用研究进行综述。

Abstract

At present, Cytokine therapy is the main strategy capable of preventing and reducing the acute radiation syndrome (ARS). With the problem of difficult match and severe graft versus host disease, haemopoietic stem cells can be used to find some effective approaches to treat acute radiation damage. Mesenchymal stem cells are of great therapeutic potential due to their particular characteristics including secretion of hematopoietic cytokine, reconstruction hemopoietic microenvironment, poor-immunogenicity, ease of reception ectogenic gene transfection and expression. This paper is to summarize the studies of biological characteristics of MSC and its application prospects in urgent radiation damage.

关键词

急性辐射损伤间充质干细胞细胞因子

Keywords

Acute radiation injuryMesenchymal stem cellsCytokine

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Related Author

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Related Institution

Department of Radiotherapy, Lanzhou General Hospital of PLA

Faculty of Naval Medicine, The Second Military Medical University

Institute of Radiation Medicine, Acadamic Military Medicial Sciences

1(Tianjin Key Lab of Molecular Nuclear Medicine, Department of Radiation Hazard Evaluation, Institute of Radiation Medicine of Chinese Academy of Medical Science and Peking Union Medical College,,)

(Naval Medical Research Institute,,)

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