Dose distribution of IMRT and 3D-CRT on treating central non-small-cell lung cancer

ZHU Xiaoyang; YU Guangwei

您当前的位置：

首页 >

文章列表页 >

Dose distribution of IMRT and 3D-CRT on treating central non-small-cell lung cancer

更新时间：2023-03-30

- Dose distribution of IMRT and 3D-CRT on treating central non-small-cell lung cancer
- Journal of Radiation Research and Radiation Processing Vol. 28, Issue 4, Pages: 254-256(2010)
- 作者机构：
  
  1.浙江大学医学院附属第二医院放疗科　杭州　310009
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
ZHU Xiaoyang, YU Guangwei. Dose distribution of IMRT and 3D-CRT on treating central non-small-cell lung cancer. [J]. Journal of Radiation Research and Radiation Processing 28(4):254-256(2010)
DOI：

ZHU Xiaoyang, YU Guangwei. Dose distribution of IMRT and 3D-CRT on treating central non-small-cell lung cancer. [J]. Journal of Radiation Research and Radiation Processing 28(4):254-256(2010) DOI：

摘要

将三维适形放疗（3D-CRT）和调强放疗（IMRT）应用于中央型非小细胞肺癌的放射治疗中，并评价了不同计划方案在剂量学上的差异性。本研究选择了32例II期中央型非小细胞肺癌患者，在CT图像的基础上，对每位患者分别做了1个3D-CRT和2个IMRT计划（5野和7野），并评价计划的剂量分布特点及其优势。结果发现，IMRT的靶区平均剂量（PTVD,mean,）和靶区最大剂量（PTVD,max,），靶区最大剂量与处方剂量的百分比（PTVD,max,（%））和靶区适形指数（CI）均比3D-CRT高，但靶区均匀指数（HI）较3D-CRT差。IMRT计划中各项肺的指标和1%体积的脊髓所接受的剂量（脊髓,D,01,）低于3D-CRT的对应值。另5野和7野的IMRT计划无显著差异。由此表明，IMRT计划能有效提高中央型非小细胞肺癌（NSCLC）的靶区剂量，又能使正常组织得到更好地保护。对应用于中央型非小细胞肺癌的IMRT，采用5野照射已完全满足临床剂量学要求。

Abstract

3D-CRT and IMRT were used in the radiation therapy of Central Non-small-cell lung cancer (NSCLC), and the dose difference of the methods was estimated. Thirty-two patients suffering with II class NSCLC were selected. Based on CT images, each patient was given 1 3D-CRT (3 dimensional conformal radiotherapy) and 2 IMRT(intensity modulated radiation therapy) treatment plans (5 fields and 7 fields), respectively, and the dose distribution was evaluated too. The results showed that PTVD,mean, and the PTV,max, PTVD,max, (%) and CI of IMRT were both higher than those of 3D-CRT, but the uniformity was not as good as 3D-CRT. All indexes of lung and spinal cord treated with IMRT were lower than that treated with 3D-CRT. Moreover, there was no significance of the difference between 5 fields and 7 fields. In a conclusion, IMRT could not only decrease the target dose of NSCLC, but it can protect normal tissue from radiation damage effectively. And when IMRT was used, 5 fields might be enough.

关键词

中央型非小细胞肺癌放射治疗三维适形放疗调强放疗

Keywords

Central non-small-cell lung cancerRadiation therapy3D-CRTIntensity modulated radiation therapy

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Inhibitory effect of recombinant adenovirus encoding human p53 tumor suppressor gene (rAd-p53) combined with radiation therapy on human lymphoma cells lines growth

双基因联合放射提高脑胶质瘤疗效的研究进展

重离子(12C6+)束治疗肝脏恶性肿瘤的初步临床结果

非共面野在植入式心脏起搏器食管癌调强放疗中的应用

Related Author

No data

Related Institution

The Second Hospital Affiliated to Suzhou University

School of Radiation Medicine and Public Health, Suzhou University

Suzhou Municipal Hospital Affiliated to Nanjing Medical University

（苏州大学医学部放射医学与防护学院，江苏省放射医学与防护重点实验室）

1(Radiotherapy Department, Tumor Hospital of Gansu Province,,)

⁰