Study on radio-protection effects of fullerene derivative C<sub>60</sub>-Lys in AHH-1 cell

CHENG Ying; HUANG Yuecheng; GAO Fu; LI Bailong; CUI Jianguo; CAI Jianming; SUN Quan

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Study on radio-protection effects of fullerene derivative C₆₀-Lys in AHH-1 cell

更新时间：2023-03-30

- Study on radio-protection effects of fullerene derivative C₆₀-Lys in AHH-1 cell
- Journal of Radiation Research and Radiation Processing Vol. 28, Issue 5, Pages: 257-261(2010)
- 作者机构：
  
  1.第二军医大学放射医学教研室　上海　200433
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CHENG Ying, HUANG Yuecheng, GAO Fu, et al. Study on radio-protection effects of fullerene derivative C₆₀-Lys in AHH-1 cell. [J]. Journal of Radiation Research and Radiation Processing 28(5):257-261(2010)
DOI：

CHENG Ying, HUANG Yuecheng, GAO Fu, et al. Study on radio-protection effects of fullerene derivative C₆₀-Lys in AHH-1 cell. [J]. Journal of Radiation Research and Radiation Processing 28(5):257-261(2010) DOI：

摘要

本文研究了富勒烯赖氨酸衍生物C,60,-Lys对AHH-1细胞的辐射防护作用，并对其防护机理进行了初步研究。发现800 mg/L C,60,-lys能提高辐照后AHH-1细胞存活率，在8 Gy照射剂量时，给药组与对照组AHH-1细胞存活率分别为64.6%和41.3%。荧光凋亡实验发现，当C,60,-lys浓度为1200 mg/L时，凋亡率为16.3%，这明显低于单纯辐照组的39.2%。在800 mg/L C,60,-lys和4 Gy辐照剂量时，给药时间对细胞存活率有显著影响，辐照前给药，AHH-1细胞平均存活率是85.6%，而辐照后给药则是64.1%。C,60,-lys降低4 Gy辐射引起的AHH-1细胞的G,2,期阻滞及辐射对AHH-1细胞DNA损伤，尤其是减少8-羟基-2'脱氧鸟嘌呤核苷(8-OHdG)含量。

Abstract

In this paper the radioprotection effects of fullerene derivative (C,60,-Lys) on AHH-1 cells and its protective mechanism have been investigated. The 800 mg/L C,60,-lys can improve the survival rate of irradiated AHH-1 cells, which are 64.6% and 41.3% for the irradiation and control groups at 8 Gy dose, respectively. The cell fluorescence images show that the 16.3% apoptosis rate at 1200 mg/L C,60,-lys is lower than that of the 39.2% irradiation free of C,60,-lys. In the situation with additive 800 mg/L C,60,-lys and 4 Gy of irradiation, the dosed time before or after irradiation significantly affects the average survival rates of AHH-1 cells, which are 85.6% and 64.1%, respectively. In the AHH-1 cells treatment with C,60,-lys can obviously reduce the G,2, blockage of AHH-1 cells induced by 4 Gy radiation, DNA damage and amount of 8-OHdG especially.

关键词

富勒烯辐射防护γ射线AHH-1细胞8-OHdG

Keywords

FullereneRadiation protectionγ- raysAHH-1 cell8-OHdG

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Study on radio-protection effects of fullerene derivative C60-Lys in AHH-1 cell

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Abstract

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Study on radio-protection effects of fullerene derivative C₆₀-Lys in AHH-1 cell