Microdosimetric research of a single cell model by Monte Carlo simulation

LIN Hui; WU Dongsheng; XU Yuanying; JING Jia; XU Liangfeng

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Microdosimetric research of a single cell model by Monte Carlo simulation

更新时间：2023-03-30

- Microdosimetric research of a single cell model by Monte Carlo simulation
- Journal of Radiation Research and Radiation Processing Vol. 28, Issue 6, Pages: 339-344(2010)
- 作者机构：
  
  1.合肥工业大学电子科学与应用物理学院　合肥　230009
  2.合肥工业大学管理学院　合肥　230009
  3.合肥工业大学计算机与信息学院　合肥　230009
- 作者简介：
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LIN Hui, WU Dongsheng, XU Yuanying, et al. Microdosimetric research of a single cell model by Monte Carlo simulation. [J]. Journal of Radiation Research and Radiation Processing 28(6):339-344(2010)
DOI：

LIN Hui, WU Dongsheng, XU Yuanying, et al. Microdosimetric research of a single cell model by Monte Carlo simulation. [J]. Journal of Radiation Research and Radiation Processing 28(6):339-344(2010) DOI：

摘要

研究电离辐射在生物体内的能量沉积及相应的生物效应时，有必要研究单个细胞或部分细胞中能量吸收的统计特性。本工作利用蒙特卡罗软件Geant4，开发了计算单细胞微观剂量学程序，依据微观剂量学理论，对α释放子,211,A,t,在单细胞模型中的微剂量学特征进行了研究。分析了不同大小细胞中单事件比能与存活分数的特点，并对真实细胞模型中微剂量学特征进行了分析。通过与简单数学模型结果对比，分析了细胞不同材料及形状对模拟结果的影响。本工作建立的体元单细胞模型为单细胞微剂量学研究提供了工具，同时也很易于扩展到真实组织模型。

Abstract

It is very important that the stochastic characteristics of the absorbed energy affect the energy deposit and its radiobiological effect of ionization radiation at cell or cell cluster scale. This work built the specific code for microdosimetric quantities based on Geant4 toolkit, and studied the α-emitter ,211,A,t ,microdosimetric characteristics of a simple cell model and a virtual cell model. The feature of the single event specific energy and the survival fraction for different cell dimensions was investigated. A virtual digital cell model was implemented and its microdosimetric characteristics were studied. The influence of different materials and irregular configuration on the microdosimetric quantities was analyzed by comparing with those of the simple cell model. A Geant4 utility code for voxel-based single cell models was built for the microdosimetric research of single cell model, which is also easy to extend to the voxel-based tissue model.

关键词

微剂量学蒙特卡罗简单细胞人体细胞

Keywords

MicrodosimetryMonte CarloSimple cell modelVirtual cell model

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