Preliminary study on bystander effect induced by ionizing radiation in vivo

CHEN Feng; TU Yu

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Preliminary study on bystander effect induced by ionizing radiation in vivo

更新时间：2023-03-30

- Preliminary study on bystander effect induced by ionizing radiation in vivo
- Journal of Radiation Research and Radiation Processing Vol. 28, Issue 6, Pages: 373-376(2010)
- 作者机构：
  
  1.苏州大学医学部放射医学与公共卫生学院　苏州　215123
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CHEN Feng, TU Yu. Preliminary study on bystander effect induced by ionizing radiation in vivo. [J]. Journal of Radiation Research and Radiation Processing 28(6):373-376(2010)
DOI：

CHEN Feng, TU Yu. Preliminary study on bystander effect induced by ionizing radiation in vivo. [J]. Journal of Radiation Research and Radiation Processing 28(6):373-376(2010) DOI：

摘要

探讨孕鼠受γ射线照射对旁效应器官胎鼠脑组织神经发育的影响。将怀孕的昆明小鼠随机分为7组：空白对照组、0.5 Gy全身照射组、0.5 Gy头部照射组、1.0 Gy全身照射组、1.0 Gy头部照射组、2.0 Gy全身照射组及2.0 Gy头部照射组。照射组用,60,Co治疗机对实验小鼠于孕9 d单次急性垂直照射，于孕18 d取胎鼠脑组织，用酶联免疫吸附法（Enzyme linked immunosorbent assay，ELISA）测定胎脑组织中乙酰胆碱酯酶（Acetylcholinesterase，AchE）及乙酰胆碱（Acetylcholine，Ach）的含量。结果显示，与空白对照组比较，0.5 Gy和1.0 Gy头部照射组胎脑Ach含量显著性降低（,p,<,0.05）；2.0 Gy头部照射组胎脑AchE及Ach含量均显著性降低（,p,<,0.05）；0.5 Gy全身照射组胎脑AchE含量明显升高（,p,<,0.05）；2.0 Gy全身照射组胎脑AchE及Ach含量均显著性降低（,p,<,0.05）。孕鼠急性头部受照，电离辐射能够诱发体内旁效应，其胎脑效应类似孕鼠急性全身照射后胎脑效应。

Abstract

In order to investigate the effect of γ-rays on neurodevelopment of fetal brain tissue as bystander effect organ, pregnant Kunming mice were randomly divided into blank control group, 0.5 Gy whole-body exposed group, 0.5 Gy head exposed group, 1.0 Gy whole-body exposed group, 1.0 Gy head exposed group, 2.0 Gy whole-body exposed group and 2.0 Gy head exposed group. The exposed mice were exposed with a vertical single acute dose using ,60,Co therapy apparatus on 9 th day of pregnancy, and cesarean operation were performed to gain fetal mice on 18 th day of pregnancy. Then the levels of AchE and Ach were detected using ELISA kit. Compared with the blank control group, the levels of Ach in 0.5 Gy and 1.0 Gy head exposed groups were decreased (,p,<,0.05); the levels of AchE and Ach decreased in 2.0 Gy whole-body and head exposed groups (,p,<,0.05); the level of Ach in 0.5 Gy whole-body exposed group increased (,p,<,0.05). And bystander effect in fetal brain tissue was induced by ionizing radiation in head exposed groups, which was similar with that in the whole-body exposed groups.

关键词

电离辐射胎脑AchEAch体内旁效应

Keywords

Ionizing radiationFetal brainAchEAchBystander effect in vivo

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