THE EFFECT OF MIXED INFUSION OF BONE MARROW CELLS AND BONE MARROW STROMAL CELLS ON HEMATOPOIETIC RECONSTITUTION IN LETHALLY IRRADIATED MICE

LIU Jing; JI Shuquan; QING Fenghua; CHEN Huiren; LIU Xiaolan; GENG Yu

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THE EFFECT OF MIXED INFUSION OF BONE MARROW CELLS AND BONE MARROW STROMAL CELLS ON HEMATOPOIETIC RECONSTITUTION IN LETHALLY IRRADIATED MICE

更新时间：2023-04-07

- THE EFFECT OF MIXED INFUSION OF BONE MARROW CELLS AND BONE MARROW STROMAL CELLS ON HEMATOPOIETIC RECONSTITUTION IN LETHALLY IRRADIATED MICE
- Journal of Radiation Research and Radiation Processing Vol. 18, Issue 3, Pages: 218-222(2000)
- 作者机构：
  
  1.空军总医院血液科　北京　100036
  2.北京放射医学研究所　北京　1000850
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LIU Jing, JI Shuquan, QING Fenghua, et al. THE EFFECT OF MIXED INFUSION OF BONE MARROW CELLS AND BONE MARROW STROMAL CELLS ON HEMATOPOIETIC RECONSTITUTION IN LETHALLY IRRADIATED MICE. [J]. Journal of Radiation Research and Radiation Processing 18(3):218-222(2000)
DOI：

LIU Jing, JI Shuquan, QING Fenghua, et al. THE EFFECT OF MIXED INFUSION OF BONE MARROW CELLS AND BONE MARROW STROMAL CELLS ON HEMATOPOIETIC RECONSTITUTION IN LETHALLY IRRADIATED MICE. [J]. Journal of Radiation Research and Radiation Processing 18(3):218-222(2000) DOI：

摘要

为观察小鼠骨髓细胞（BMC）及骨髓基质细胞（BMSC）混合输注对受致死剂量照射小鼠造血重建的影响，给予受致死剂量照射的Balb/c小鼠输注同基因BMC 1×10,7,个及经体外扩增的同基因原代BMSC 2×10,5,个，并与单纯骨髓移植组进行了比较。结果表明，移植后第14天外周血白细胞、血小板回升较快，第15天、第20天粒–单系祖细胞（CFU-GM）、红系祖细胞（BFU-E、CFU-E）、造血干细胞（CFU-S）明显高于后者，第20天已达正常。说明原代BMSC不仅可以移植，而且能够加快造血重建，提高移植效果。

Abstract

To observe the effect of mixed infusion of bone marrow and bone marrow stromal cells on hematopoietic reconstitution in lethally irradiated mice, Balb/c mice irradiated lethally received 1×10,7, syngeneic bone marrow cells and 2×10,5, syngeneic bone marrow stromal cells via the intravenous route. As compared with the simple BMT group, the WBC and the BPC in peripheral blood in mixed infusion group recover more quickly on day 14 after BMT and BMSCT. The numbers of CFU-GM, BFU-E, CFU-E, CFU-S in mixed infusion group are higher than that of the simple BMT group on day 15 and day 20 after BMT and BMSCT. Conclusion: primary cultured bone marrow stromal cells not only is transplantable, but also can accelerate hematopoietic reconstitution.

关键词

骨髓移植骨髓基质细胞体外扩增造血重建

Keywords

Bone marrow transplantationBone marrow stromal cellsIn vitro proliferationHematopoietic reconstitution

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