ONE-ELECTRON OXIDATION OF dGMP BY OXIDIZED RIBOFLAVIN RADICAL IN AQUEOUS SOLUTION: A LASER FLASH PHOTOLYSIS STUDY

LU Changyuan; HAN Zhephui; WANG Wenfeng; LIN Weizhen; Zhang Lianwen; YAO Side; LIN Nianyun

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ONE-ELECTRON OXIDATION OF dGMP BY OXIDIZED RIBOFLAVIN RADICAL IN AQUEOUS SOLUTION: A LASER FLASH PHOTOLYSIS STUDY

更新时间：2023-04-13

- ONE-ELECTRON OXIDATION OF dGMP BY OXIDIZED RIBOFLAVIN RADICAL IN AQUEOUS SOLUTION: A LASER FLASH PHOTOLYSIS STUDY
- Journal of Radiation Research and Radiation Processing Vol. 18, Issue 4, Pages: 268-271(2000)
- 作者机构：
  
  1.中国科学院上海原子核研究所辐射化学开放实验室　上海　201800
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LU Changyuan, HAN Zhephui, WANG Wenfeng, et al. ONE-ELECTRON OXIDATION OF dGMP BY OXIDIZED RIBOFLAVIN RADICAL IN AQUEOUS SOLUTION: A LASER FLASH PHOTOLYSIS STUDY. [J]. Journal of Radiation Research and Radiation Processing 18(4):268-271(2000)
DOI：

LU Changyuan, HAN Zhephui, WANG Wenfeng, et al. ONE-ELECTRON OXIDATION OF dGMP BY OXIDIZED RIBOFLAVIN RADICAL IN AQUEOUS SOLUTION: A LASER FLASH PHOTOLYSIS STUDY. [J]. Journal of Radiation Research and Radiation Processing 18(4):268-271(2000) DOI：

摘要

应用248nm激光光解时间分辨吸收方法，研究了2'-鸟嘌呤核苷酸与核黄素氧化性自由基之间的单电子转移机理，给出了电子转移的直接证据。改变溶液的酸碱性，探讨了不同形式自由基之间电子转移的可行性。

Abstract

Using time-resolved technique of 248nm laser flash photolysis, electron transfer from 2'-deoxyguanosine-5'-monophosphate (dGMP) to oxidized riboflavin (VB,2,) radical was observed for the first time due to the buildup of the oxidized dGMP radical matching the decay of oxidized riboflavin radical at different pH values in aqueous solution. The reaction rate constants were derived to be 5.6×10,8, 5.8×10,8, and 6.2×10,8,dm,3,•mol,-1,•s,-1, at pH 3, 5 and 7.5, respectively. The direct observation of oxidized guanine radical has provided unambiguously direct initial proof for photosensitization process of dGMP by oxidized riboflavin radical.

关键词

核黄素2'-鸟嘌呤核苷酸氧化性自由基电子转移激光光解

Keywords

RiboflavindGMPOxidized radicalElectron transferLaser flash photolysis

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