METALLOTHIONEIN EXPRESSION IN MOUSE IMMUNE ORGAN INDECED BY RADIATION

JU Guizhi; FAN Cai; LIU Shuzheng

您当前的位置：

首页 >

文章列表页 >

METALLOTHIONEIN EXPRESSION IN MOUSE IMMUNE ORGAN INDECED BY RADIATION

更新时间：2023-04-13

- METALLOTHIONEIN EXPRESSION IN MOUSE IMMUNE ORGAN INDECED BY RADIATION
- Journal of Radiation Research and Radiation Processing Vol. 18, Issue 4, Pages: 308-311(2000)
- 作者机构：
  
  1.白求恩医科大学卫生部放射生物学重点实验室　长春　130021
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
JU Guizhi, FAN Cai, LIU Shuzheng. METALLOTHIONEIN EXPRESSION IN MOUSE IMMUNE ORGAN INDECED BY RADIATION. [J]. Journal of Radiation Research and Radiation Processing 18(4):308-311(2000)
DOI：

JU Guizhi, FAN Cai, LIU Shuzheng. METALLOTHIONEIN EXPRESSION IN MOUSE IMMUNE ORGAN INDECED BY RADIATION. [J]. Journal of Radiation Research and Radiation Processing 18(4):308-311(2000) DOI：

摘要

观察了电离辐射对金属硫蛋白（MT）在免疫器官中表达的影响。采用放射性,109,Cd血红蛋白亲和分析法检测组织中MT含量。观察0.5、2、4、6Gy X射线全身照射后16h，及4Gy全身照射后0.5、2、4、8、16、24、48、72h，昆明小鼠胸腺及脾脏中MT含量的变化。结果发现，在0.5～6Gy剂量范围内胸腺中MT含量呈剂量依赖性增高，其中，4Gy和6Gy组有统计学意义（,p,<,0.05）。4Gy X射线照射后8～48h胸腺中MT含量显著增高(,p,<,0.05～,p,<,0.001)。然而，量效及时效研究均未见脾脏中MT含量的变化。以上结果表明，X射线能诱导MT在免疫器官中表达，但表现出明显的组织特异性。

Abstract

To explore the effect of ionizing radiation on the expression of metallothionein (MT) in immune organs, the ,109,Cd-hamoglobulin affinity assay was employed to measure the content of MT in tissues. The dose effect relationship of the MT expression in mouse thymus and spleen was investigated 16h after exposure to 0.5, 1, 2, 4 and 6Gy whole body irradiation(WBI). And the time course changes in MT expression in mouse thymus and spleen were also determined at different time intervals after 4Gy WBI. The results showed that the MT content in mouse thymus was significantly increased 16h after 4Gy and 6Gy irradiation compared with that in sham-irradiated mice (p ,<,0.05, respectively). And it was found that the MT content in mouse thymus was also increased significantly from 8h to 48h after 4Gy irradiation compared with that in sham-irradiated mice (,p,<, 0.05 ~,p,<,0.001). However, there were no markedly changes for the MT expression in the mouse spleen after exposure to X rays. These results mentioned above suggest that the MT expression in immune organs could be induced by X rays, which may be tissue-specific.

关键词

电离辐射金属硫蛋白胸腺脾脏

Keywords

Ionizing radiationMetallothioneinThymusSpleen

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of CpG-ODN on spleen damage after carbon ion radiation

Protective effects of a Chinese medicinal formula on the spleen of irradiated mice

Preparation of hydrogel-based photocatalytic composite materials by radiation technology

Clustered DNA damages induced by low-energy (1~20 eV) electrons and the general mechanism of transient anions

Research progress on the effect of water types on H₂ production in cement solidification treatment

Related Author

No data

Related Institution

Department of Radiotherapy, The Hospital of Joint Logistic Support Force of PLA

Faculty of Naval Medicine, Naval Military Medical University

Hubei University of Arts and Science, Xiangyang

Naval Medical Center of the PLA

Panzhihua Health Commission

⁰