DYNAMIC OBSERVATION OF MICRONUCLEI AND CELL SURVIVAL IN HUMAN LIVER CANCER CELLS IRRADIATED BY HEAVY ION

Li Wenjian; Zhou Guangming; Chen Weiqiang; Wei Zengquan; Xie Hongmei; Dang Bingrong; Li Qiang; Han Guangwu; Zhang Shumin; Huang Tao; Gao Qingxiang; Yang Hanmin

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DYNAMIC OBSERVATION OF MICRONUCLEI AND CELL SURVIVAL IN HUMAN LIVER CANCER CELLS IRRADIATED BY HEAVY ION

更新时间：2023-04-18

- DYNAMIC OBSERVATION OF MICRONUCLEI AND CELL SURVIVAL IN HUMAN LIVER CANCER CELLS IRRADIATED BY HEAVY ION
- Journal of Radiation Research and Radiation Processing Vol. 16, Issue 1, Pages: 15-19(1998)
- 作者机构：
  
  1.中国科学院近代物理研究所　兰州　730000
  2.兰州大学生物系　兰州　730000
- 作者简介：
- 基金信息：
  
  Special Foundation of The State Science & Technology Commission
- DOI：
  CLC：
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Li Wenjian, Zhou Guangming, Chen Weiqiang, et al. DYNAMIC OBSERVATION OF MICRONUCLEI AND CELL SURVIVAL IN HUMAN LIVER CANCER CELLS IRRADIATED BY HEAVY ION. [J]. Journal of Radiation Research and Radiation Processing 16(1):15-19(1998)
DOI：

Li Wenjian, Zhou Guangming, Chen Weiqiang, et al. DYNAMIC OBSERVATION OF MICRONUCLEI AND CELL SURVIVAL IN HUMAN LIVER CANCER CELLS IRRADIATED BY HEAVY ION. [J]. Journal of Radiation Research and Radiation Processing 16(1):15-19(1998) DOI：

摘要

研究了,25,MeV/u,40,Ar,14+,辐照人肝癌细胞SMMC-7721的微核及存活的动态变化。结果表明：单次照射与分次照射的微核率随时间的变化规律没有明显区别。受辐照（单次、分次）肝癌细胞的生长明显低于对照，而且随培养时间的延长，癌细胞的存活数表现出衰减趋势。微核率与细胞存活数关系的动态变化为负相关性。0.68、6.8和68Gy辐照的细胞，培养24h的微核率比培养96h的微核率低，培养24h和48h的肝癌细胞的存活数与剂量均呈负相关性。

Abstract

This paper reported dynamic changes of micronuclei and cell survival in human liver cancer cells SMMC-7721 irradiated by 25MeV/u,40,Ar,14+,. The results show: (1) Change rules of frequency of micronuclei induced by single irradiation and fractionation irradiation with culture time have not clear difference. (2) Irradiated (single, fractionation) liver cancer cells grow much slower than control and their survival number with culture time shows decay tendency. (3) Dynamic changes of the relationship between micronucleus frequency and cell survival number presents negative correlation. (4) For cells irraddiated by dose of 0.68Gy, 6.8Gy and 68Gy,frequency of micronuclei following culture 24 hours is lower than that following culture 96 hours. (5) Negative dependences of survival number of liver cancer cells for culture 24 hours and 48 hours on dose are demenstrated.

关键词

肝癌细胞重离子微核存活数

Keywords

Liver cancer cellHeavy ionMicronucleusSurvival number

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