RADIOSENSITIVITY OF THYMOCYTES IN DIFFERENT STAGES OF THEIR DIFFERENTIATION

Su Xu; Zhang Yingchun; Liu Shuzheng

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RADIOSENSITIVITY OF THYMOCYTES IN DIFFERENT STAGES OF THEIR DIFFERENTIATION

更新时间：2023-04-18

- RADIOSENSITIVITY OF THYMOCYTES IN DIFFERENT STAGES OF THEIR DIFFERENTIATION
- Journal of Radiation Research and Radiation Processing Vol. 16, Issue 1, Pages: 38-41(1998)
- 作者机构：
  
  1.白求恩医科大学卫生部放射生物重点实验室　长春　130021
- 作者简介：
- 基金信息：
  
  The National Science Foundation of China
- DOI：
  CLC：
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Su Xu, Zhang Yingchun, Liu Shuzheng. RADIOSENSITIVITY OF THYMOCYTES IN DIFFERENT STAGES OF THEIR DIFFERENTIATION. [J]. Journal of Radiation Research and Radiation Processing 16(1):38-41(1998)
DOI：

Su Xu, Zhang Yingchun, Liu Shuzheng. RADIOSENSITIVITY OF THYMOCYTES IN DIFFERENT STAGES OF THEIR DIFFERENTIATION. [J]. Journal of Radiation Research and Radiation Processing 16(1):38-41(1998) DOI：

摘要

采用免疫荧光流式细胞术研究了胸腺细胞及其亚组的辐射效应。结果表明：胸腺细胞具有较高的辐射敏感性，并且在胸腺细胞成熟分化的不同阶段辐射敏感性不同。成熟的胸腺细胞具有相对的辐射抗性。各亚组辐射敏感性依次为：CD4,+, CD8,+,>,CD4,-, CD8,-,>,CD4,-, CD8,+,>,CD4,+, CD8,-,，D,37,值分别为0.76、0.92、1.77 Gy和3.67 Gy。全胸腺细胞的D,37,为0.84 Gy。CD3,+,细胞的D,37,值为2.0 Gy。

Abstract

Kunming mice were wholoe—body irradiated with 0.5~4.0 Gy X—rays. The effeet on different subset of thymocytes were analyzed by flow cytometry with fluorescent monoclonal antibodies 24 hour after irradiation. The results showed that the radiosensitivity varied in different stages of differentiation of the thymocytes. The order of radiosensitivity was: CD4,+, CD8,+,>,CD4,-,CD8,-,>,CD4,-,CD8,+,>,CD4,+,CD8,-,suggesting a relative rad ioresistance of the mature thymocytes. The D,37, values of CD4,+,CD8,+, CD4,-,CD8,-, CD4,-,CD8,+, and CD4,+, CD8,-, subsets were respectively 0.76, 0.92, 1.77 Gy and 3.67 Gy. The D,37, value of the thymocytes as a whole population was 0.84 Gy. The D,37, value of CD3,+, cell was 2.0 Gy.

关键词

胸腺细胞成熟分化辐射敏感性辐射效应

Keywords

ThymocytesDifferentiationRadiosensitivityRadiation effect

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