EFFECT OF LOW DOSE RADIATION ON [Ca<sup>2+</sup>]i IN THYMOCYTES

Xie Feng; Su Xu; Liu Shuzheng

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EFFECT OF LOW DOSE RADIATION ON [Ca²⁺]i IN THYMOCYTES

更新时间：2023-04-18

- EFFECT OF LOW DOSE RADIATION ON [Ca²⁺]i IN THYMOCYTES
- Journal of Radiation Research and Radiation Processing Vol. 16, Issue 1, Pages: 42-44(1998)
- 作者机构：
  
  1.白求恩医科大学卫生部放射生物重点实验室　长春　130021
- 作者简介：
- 基金信息：
  
  The National Science Foundation of China
- DOI：
  CLC：
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Xie Feng, Su Xu, Liu Shuzheng. EFFECT OF LOW DOSE RADIATION ON [Ca²⁺]i IN THYMOCYTES. [J]. Journal of Radiation Research and Radiation Processing 16(1):42-44(1998)
DOI：

Xie Feng, Su Xu, Liu Shuzheng. EFFECT OF LOW DOSE RADIATION ON [Ca²⁺]i IN THYMOCYTES. [J]. Journal of Radiation Research and Radiation Processing 16(1):42-44(1998) DOI：

摘要

应用Fum-2AM荧光探针研究了低剂量X射线照射后24 h昆明鼠胸腺细胞游离钙浓度的变化。结果表明：75 mGy全身照射后胸腺细胞[Ca,2+,],i,明显高于对照组，而加入次佳浓度的ConA则使[Ca,2+,],i,较单纯照射更明显增高。提示低剂量辐射可促进T淋巴细胞的信号传递。

Abstract

Kunming mice were whole body irradiated with different doses of X-rays. Changes of cytosolic-free calcium concentration in thymocytes were measured using Fura-2AM as fluorescent probe. It was found that [Ca,2+,],i, increased 24 h after WBI with 75~100 mGy X-rays. and the increase in [Ca,2+,],i, of thymocytes was fonud to be more marked in the presence of ConA stimulation. The results indicate that low dose radiation can promote signaltransduction of T lymphocytes.

关键词

低剂量辐射胸腺细胞[Ca2+]i信号传递Fura-2AM

Keywords

Low dose radiationThymocyteCytosolic-free calcium concentrationSignal transmissionFura-2AM

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Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College

Institute of Material Medical, Chinese Academy of Medical Sciences, Peking Union Medical College

Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Peking Union Medical College

Department of Toxicology, School of Public Health, Jilin University

MH Radiobiology Research Unit, School of Public Health, Jilin University

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EFFECT OF LOW DOSE RADIATION ON [Ca2+]i IN THYMOCYTES

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摘要

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EFFECT OF LOW DOSE RADIATION ON [Ca²⁺]i IN THYMOCYTES