RADIATION INDUCED HPRT GENE MUTATION OF HAEMOPOIETIC PROGENITOR CELL IN MICE

Yang Fengtong; Sun Yuanming; Cui Huishuang

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RADIATION INDUCED HPRT GENE MUTATION OF HAEMOPOIETIC PROGENITOR CELL IN MICE

更新时间：2023-04-18

- RADIATION INDUCED HPRT GENE MUTATION OF HAEMOPOIETIC PROGENITOR CELL IN MICE
- Journal of Radiation Research and Radiation Processing Vol. 16, Issue 1, Pages: 62-64(1998)
- 作者机构：
  
  1.中国医学科学院|中国协和医科大学　放射医学研究所　天津　300192
- 作者简介：
- 基金信息：
  
  The National Science Foundation of China(39170270)
- DOI：
  CLC：
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Yang Fengtong, Sun Yuanming, Cui Huishuang. RADIATION INDUCED HPRT GENE MUTATION OF HAEMOPOIETIC PROGENITOR CELL IN MICE. [J]. Journal of Radiation Research and Radiation Processing 16(1):62-64(1998)
DOI：

Yang Fengtong, Sun Yuanming, Cui Huishuang. RADIATION INDUCED HPRT GENE MUTATION OF HAEMOPOIETIC PROGENITOR CELL IN MICE. [J]. Journal of Radiation Research and Radiation Processing 16(1):62-64(1998) DOI：

摘要

研究了单次和分次,137,Csγ射线照射所致辐射残留损伤小鼠骨髓粒、巨噬系造血祖细胞（GM-CFU）的HPRT基因突变。结果证明单次照射时突变频率与照射剂量密切相关。总剂量相同的分次照射与单次照射的结果未见差异。辐射防护药WR-2721对HPRT基因突变有防护作用。

Abstract

The HPRT gene mutation of haemopoietic progenitor cells (GM-CFU) in mice suffered from residual injury induced by single dose and fractional dose ,137,Cs γ-ray irradiation were investigated. The results showed that the mutant frequency of GM-CFU related closly to the radiation dose. No significant differences were found between single dose and fractional dose irradiation when total dose were 6.0Gy. The radioprotective agent, WR-2721, expressed a obvious protecitive function to HPRT gene mutation of bone marrow GM-CFU in mice.

关键词

γ辐射HPRT基因突变造血祖细胞GM-CFU

Keywords

γ-radiationHPRT gene mutationHaemopoietic progenitor cellsGM-CFU

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