ADAPTIVE RESPONSE OF THYMOCYTE APOPTOSIS AND CELL CYCLE PROGRESSION INDUCED BY LOW DOSE RADIATION

Gong Shouliang; Liu Shuchun; Zhang Yingchun; Liu Shuzheng

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ADAPTIVE RESPONSE OF THYMOCYTE APOPTOSIS AND CELL CYCLE PROGRESSION INDUCED BY LOW DOSE RADIATION

更新时间：2023-04-18

- ADAPTIVE RESPONSE OF THYMOCYTE APOPTOSIS AND CELL CYCLE PROGRESSION INDUCED BY LOW DOSE RADIATION
- Journal of Radiation Research and Radiation Processing Vol. 16, Issue 3, Pages: 150-152(1998)
- 作者机构：
  
  1.白求恩医科大学放射生物教研室　长春　130021
- 作者简介：
- 基金信息：
  
  The National Natural Science Foundation of China
- DOI：
  CLC：
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Gong Shouliang, Liu Shuchun, Zhang Yingchun, et al. ADAPTIVE RESPONSE OF THYMOCYTE APOPTOSIS AND CELL CYCLE PROGRESSION INDUCED BY LOW DOSE RADIATION. [J]. Journal of Radiation Research and Radiation Processing 16(3):150-152(1998)
DOI：

Gong Shouliang, Liu Shuchun, Zhang Yingchun, et al. ADAPTIVE RESPONSE OF THYMOCYTE APOPTOSIS AND CELL CYCLE PROGRESSION INDUCED BY LOW DOSE RADIATION. [J]. Journal of Radiation Research and Radiation Processing 16(3):150-152(1998) DOI：

摘要

应用流式细胞术观察75mGy X射线诱导小鼠胸腺细胞凋亡及细胞周期进程的适应性反应。结果表明，1.5或2.0 Gy全身照射后，小鼠胸腺细胞凋亡小体（TAB）百分数明显增加，S期TAB百分数明显减少，而G,0,/G,1,和G,2,+M期TAB百分数明显增加；当1.5或2.0Gy（攻击剂量，D,2,）照射前6h给予75mGy（诱导剂量，D,1,）照射时，明显减轻D,2,对胸腺细胞凋亡及细胞周期进程的损伤作用。提示，低剂量辐射可诱导胸腺细胞凋亡及细胞周期进程的适应性反应。

Abstract

The adaptive response of thymocyte apoptosis and cell cycle progression induced by 75mGy X-rays in mice were observed. The percentages of thymocyte apoptotic bodies (TAB) and cell cycle phase count were examined with flow cytometry. It was found that the percentages of TAB increased,the percentages of S phase cells decreased and the percentages of G,0,/G,1, and G,2,+M phase cells increased after whole-body irradiation with 1.5 or 2.0Gy in mice,all were significant statistically,as compared with sham-irradiation. When the mice were irradiated with 75mGy (inductive dose,D,1,) 6h before 1.5 or 2.0Gy (challenge dose, D,2,) exposure,the damage effects of D,2, on thymocyte apoptosis and cell cycle progression were obviously weaked. Low dose radiation may induce the adaptive response of thymocyte apoptosis and cell cycle progression.

关键词

低剂量辐射适应性反应细胞凋亡细胞周期进程

Keywords

Low dose radiationAdaptive responseApoptosisCell cycle progression

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