INDUCTION OF RADIORESISTANCE IN HUMAN LYMPHOCYTES BY PREHEAT TREATMENT

Jiang Jie; Cai Lu; Wang Xianli

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INDUCTION OF RADIORESISTANCE IN HUMAN LYMPHOCYTES BY PREHEAT TREATMENT

更新时间：2023-04-23

- INDUCTION OF RADIORESISTANCE IN HUMAN LYMPHOCYTES BY PREHEAT TREATMENT
- Journal of Radiation Research and Radiation Processing Vol. 10, Issue 4, Pages: 232-235(1992)
- 作者机构：
  
  1.白求恩医科大学，长春　130021
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Jiang Jie, Cai Lu, Wang Xianli. INDUCTION OF RADIORESISTANCE IN HUMAN LYMPHOCYTES BY PREHEAT TREATMENT. [J]. Journal of Radiation Research and Radiation Processing 10(4):232-235(1992)
DOI：

Jiang Jie, Cai Lu, Wang Xianli. INDUCTION OF RADIORESISTANCE IN HUMAN LYMPHOCYTES BY PREHEAT TREATMENT. [J]. Journal of Radiation Research and Radiation Processing 10(4):232-235(1992) DOI：

摘要

人离体血淋巴细胞在G,0,、G,1,、S和G,2,期分别给予41℃ 1 h加热、50 mGy小剂量照射或50 mGy和41℃1 h加热联合作用，培养至48 h再给1.5 GyX射线照射。结果表明三种预先处理的染色单体畸变率均明显低于单纯1.5 Gy组，说明加热和小剂量X射线一样，可诱导细胞对电离辐射的抗性。但50 mGy和41℃1 h加热联合作用的适应性反应未见累加作用，因此认为低剂量辐射和加热所诱导的适应性反应的机制可能是一致的，即通过热休克蛋白而产生保护作用。

Abstract

Human lymphocytes pre-treated by heat (41℃ 1 h), low dose irradiation (50 mGy), or both low dose radiation and heat together, became less susceptible to chromatid damage induced by subsequent high dose of X-rays. Either heat or low dose X-rays could significantly reduced the yield of chromatid aberrations, but the magnitude of adaptive response was not enhanced when combined treatment with low dose radiation and heat were used. The results implied that the mechanism of adaptive response induced by low dose X-rays was as same as the mechanism of adaptive response induced by hyperthermia, which may be related with some protective proteins.

关键词

加热电离辐射染色单体畸变适应性反应热休克蛋白

Keywords

HyperthermiaRadiationChromatid aberrationAdaptive responseHeat shock protein

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