GENE MUTATION INDUCED BY <italic style="font-style: italic">γ-</italic> IRRADIATION IN MAMMALIAN CELLS

Ji Shouping; Zhang Yangpei

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GENE MUTATION INDUCED BY γ- IRRADIATION IN MAMMALIAN CELLS

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- GENE MUTATION INDUCED BY γ- IRRADIATION IN MAMMALIAN CELLS
- Journal of Radiation Research and Radiation Processing Vol. 12, Issue 1, Pages: 7-10(1994)
- 作者机构：
  
  1.军事医学科学院放射医学研究所，北京　100850
- 作者简介：
- 基金信息：
  
  National Natural Science Foundation of China
- DOI：
  CLC：
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Ji Shouping, Zhang Yangpei. GENE MUTATION INDUCED BY γ- IRRADIATION IN MAMMALIAN CELLS. [J]. Journal of Radiation Research and Radiation Processing 12(1):7-10(1994)
DOI：

Ji Shouping, Zhang Yangpei. GENE MUTATION INDUCED BY γ- IRRADIATION IN MAMMALIAN CELLS. [J]. Journal of Radiation Research and Radiation Processing 12(1):7-10(1994) DOI：

摘要

观察了电离辐射对中国仓鼠细胞CHO-K,1,和人细胞HeLa MR的非必需基因hprt和必需基因Na,+,/K,+,ATP酶的基因致突能力。γ射线能增加两种细胞hprt基因的突变频率，照射剂量和突变频率呈正相关，在相同的照射剂量下CHO-K,1,的突变频率高于HeLa MR，提示在hprt位点，鼠细胞对辐射的敏感性比人细胞高。在Na,+,/K+ATP酶基因位点，辐射不能增加两种细胞的突变频率。HPRT和Na,+,/K,+,ATP酶活分析证实了实验的可靠性。

Abstract

CHO-K,1, and HeLa MR cells were irradiated with ,60,Co γ-ray, the mutagenesis of one nonessential gene (hprt) and an essential gene (Na,+,/K,+, ATPase gene) have been observed. Enzyme assay confirmed the results of mutation induction. At hprt locus, γ-irradiation increased the mutation frequency of both cell lines and there was a linear relationship between mutation frequency and exposure dose. The mutagenecity of CHO-K,1, was higher than that of HeLa MR cells. The results indicated that hprt gene was more susceptible to mutagenesis in hamster cells than that in human cells induced by γ-ray. No induced mutation was found in both CHO-K,1, and HeLa MR cells at Na,+,/K,+, ATP ase gene locus.

关键词

γ辐射哺乳动物细胞基因突变辐射细胞效应酶

Keywords

γ-radiationMammalian cellGene mutationCellular radiation effectsEnzyme

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GENE MUTATION INDUCED BY γ- IRRADIATION IN MAMMALIAN CELLS

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