RADIOPROTECTIVE EFFECT OF METALLOTHIONEIN ON THYMINE

Fang Xingwang; Wu Jilan; Wei Genshuan

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RADIOPROTECTIVE EFFECT OF METALLOTHIONEIN ON THYMINE

更新时间：2023-04-23

- RADIOPROTECTIVE EFFECT OF METALLOTHIONEIN ON THYMINE
- Journal of Radiation Research and Radiation Processing Vol. 12, Issue 1, Pages: 1-6(1994)
- 作者机构：
  
  1.北京大学技术物理系，北京　100871
- 作者简介：
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Fang Xingwang, Wu Jilan, Wei Genshuan. RADIOPROTECTIVE EFFECT OF METALLOTHIONEIN ON THYMINE. [J]. Journal of Radiation Research and Radiation Processing 12(1):1-6(1994)
DOI：

Fang Xingwang, Wu Jilan, Wei Genshuan. RADIOPROTECTIVE EFFECT OF METALLOTHIONEIN ON THYMINE. [J]. Journal of Radiation Research and Radiation Processing 12(1):1-6(1994) DOI：

摘要

用竞争动力学方法测定了金属硫蛋白清除OH自由基的速率常数，研究了在N,2,O饱和的水溶液中金属硫蛋白对胸腺嘧啶的辐射保护作用。结果表明金属硫蛋白能有效地清除OH，对胸腺嘧啶有良好的保护作用。对胸腺嘧啶的氧饱和甲酸钠水溶液γ辐解产物分析表明，O,2,-,和H,2,O,2,不会直接造成胸腺嘧啶的损伤。

Abstract

The reaction rate of metallothionein (MT) with hydroxyl radical was determined to be ca. 10,12,mol,-1,•L•s,-1, by studying the kinetic competition of MT with ferrocyanide for OH which was generated in situ by irradiation. Radioprotective effect of MT on thymine was studied in N,2,O-saturated phosphate buffer solutions at pH 7.0. Both isoforms of rabbit MT can protect thymine against radiation damage effectively, and their effectiveness is in the order of ZnMT-1 ,>, ZnMT-2,>,(Cd,Zn) MT-1 ,>,(Cd,Zn)MT-2. However,the dose reducing factor was less than expected, which was possibly due to the secondary reactions of RS with thymine or T(OH) radicals with MT. Radiation effect on thymine in O,2,-saturated 0.1 mol•L,-1, HCOONa Solution was also studied, and the results showed that O,2,-, and H,2,O,2, didn't cause direct damage to thymine.

关键词

金属硫蛋白胸腺嘧啶辐射保护动力学分析法

Keywords

MetallothioneinThymineRadioprotectionKinetic analysis

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