STUDY ON ANTICARINOGEN DELAYED RELEASE CYTARABINE PREPARED BY RADIATION POLYMERIZATION

Xie Huaijiang; Song Juzhong; Peng Tao

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STUDY ON ANTICARINOGEN DELAYED RELEASE CYTARABINE PREPARED BY RADIATION POLYMERIZATION

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- STUDY ON ANTICARINOGEN DELAYED RELEASE CYTARABINE PREPARED BY RADIATION POLYMERIZATION
- Journal of Radiation Research and Radiation Processing Vol. 12, Issue 1, Pages: 47-51(1994)
- 作者机构：
  
  1.沈阳军区后勤部军事医学研究所，沈阳　110031
- 作者简介：
- 基金信息：
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Xie Huaijiang, Song Juzhong, Peng Tao. STUDY ON ANTICARINOGEN DELAYED RELEASE CYTARABINE PREPARED BY RADIATION POLYMERIZATION. [J]. Journal of Radiation Research and Radiation Processing 12(1):47-51(1994)
DOI：

Xie Huaijiang, Song Juzhong, Peng Tao. STUDY ON ANTICARINOGEN DELAYED RELEASE CYTARABINE PREPARED BY RADIATION POLYMERIZATION. [J]. Journal of Radiation Research and Radiation Processing 12(1):47-51(1994) DOI：

摘要

报告了甲基丙烯酸酯类在室温下进行辐射聚合制备缓释抗癌药阿糖胞苷（Ara-C）的研究结果。结果表明，不仅亲水性单体，而且疏水性单体（包括MMA、EMA和BMA等）都可用于辐射固化。加入到亲水性基质中的疏水性单体可以延缓药物的离体释放，其顺序是MMA

Abstract

This paper reported results which the anticancer drugs Ara-C with controlled slow release were made by radiation-induced polymerization of monomers such as methacrylates at room temperature. Studies showed that not only hydrophilic synthetic polymers but also hydrophobic polymers such as hydrophobic methacrylates(including MMA, EMA, and BMA) could be used to the immobilization. The hydrophobic monomer added in the hydrophilic matrix could retard the release of drug in vitro. The order is MMA

关键词

抗癌药延缓释放阿糖胞苷辐射聚合甲基丙烯酸酯类

Keywords

AnticarinogenDrug delayed releaseCytarabineRadiation polymerizationMethacrylates

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