RECOVERY CHARACTERISTICS OF MICE GRANULOCYTE-MACROPHAGE PROGENITOR CELLS FROM IRRADIATION

Wang Tao; Wang Hongyun; Cao Xia

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RECOVERY CHARACTERISTICS OF MICE GRANULOCYTE-MACROPHAGE PROGENITOR CELLS FROM IRRADIATION

更新时间：2023-04-23

- RECOVERY CHARACTERISTICS OF MICE GRANULOCYTE-MACROPHAGE PROGENITOR CELLS FROM IRRADIATION
- Journal of Radiation Research and Radiation Processing Vol. 12, Issue 1, Pages: 52-54(1994)
- 作者机构：
  
  1.苏州医学院，苏州　215007
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Wang Tao, Wang Hongyun, Cao Xia. RECOVERY CHARACTERISTICS OF MICE GRANULOCYTE-MACROPHAGE PROGENITOR CELLS FROM IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 12(1):52-54(1994)
DOI：

Wang Tao, Wang Hongyun, Cao Xia. RECOVERY CHARACTERISTICS OF MICE GRANULOCYTE-MACROPHAGE PROGENITOR CELLS FROM IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 12(1):52-54(1994) DOI：

摘要

运用粒-巨噬细胞集落（CFU-GM）体外培养技术，观察了受次致死剂量,60,Co γ射线照射的小鼠骨髓CFU-GM的修复能力。实验测得正常小鼠每根股骨中CFU-GM的总数和骨髓有核细胞总数分别为4.89×10,4,和2.4×10,7,，经6 Gy剂量照射后第3 d，两计数值分别下降到正常值的0.8%和4%，照射后第5 d出现回升。骨髓有核细胞计数和外周血白细胞数与CFU-GM的变化规律相一致。

Abstract

Recovery capability of murine bone marrow progenitor cells after whole body irradiation with sublethal dose γ-ray was observed using the method of granulocyte-macrophage colony forming unit (CFU-GM) determination in vitro. The results indicated that normal numbers of CFU-GM and nucleated cells in bone marrow per femur were 4.89×10,4, and 2.4×10,7, respectively.The third day after irradiation both values described as above decreased to 0.8% and 4% of the normal respectively. The number of cells began to increase after the 5 th day.The numbers of nucleated cells in bone marrow and counts of WBC in peripheral blood changed in correspondence with the changes of numbers of CFU-GM.

关键词

粒-巨噬细胞集落（CFU-GM）增殖分化造血祖细胞γ辐射生物辐射效应

Keywords

Granulocyte-macrophage colony forming unit (CFU-GM)ProliferationDifferentiationHaemopoietic progenitor cellsγ-radiationBiological radiation effects

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