EFFECT OF SPLENOCYTE EXTRACELLULAR FLUID IRRADIATED WITH LOW DOSE X-RAYS ON THYMOCYTE APOPTOSIS AFTER LARGER DOSE X-IRRADIATION IN MICE

Gong Shouliang; Liu Jianxiang; Liu Shuchun; Zhang Yingchun; Liu Shuzheng

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EFFECT OF SPLENOCYTE EXTRACELLULAR FLUID IRRADIATED WITH LOW DOSE X-RAYS ON THYMOCYTE APOPTOSIS AFTER LARGER DOSE X-IRRADIATION IN MICE

更新时间：2023-04-23

- EFFECT OF SPLENOCYTE EXTRACELLULAR FLUID IRRADIATED WITH LOW DOSE X-RAYS ON THYMOCYTE APOPTOSIS AFTER LARGER DOSE X-IRRADIATION IN MICE
- Journal of Radiation Research and Radiation Processing Vol. 15, Issue 1, Pages: 36-39(1997)
- 作者机构：
  
  1.白求恩医科大学放射生物教研室　长春　130021
- 作者简介：
- 基金信息：
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Gong Shouliang, Liu Jianxiang, Liu Shuchun, et al. EFFECT OF SPLENOCYTE EXTRACELLULAR FLUID IRRADIATED WITH LOW DOSE X-RAYS ON THYMOCYTE APOPTOSIS AFTER LARGER DOSE X-IRRADIATION IN MICE. [J]. Journal of Radiation Research and Radiation Processing 15(1):36-39(1997)
DOI：

Gong Shouliang, Liu Jianxiang, Liu Shuchun, et al. EFFECT OF SPLENOCYTE EXTRACELLULAR FLUID IRRADIATED WITH LOW DOSE X-RAYS ON THYMOCYTE APOPTOSIS AFTER LARGER DOSE X-IRRADIATION IN MICE. [J]. Journal of Radiation Research and Radiation Processing 15(1):36-39(1997) DOI：

摘要

75mGy,X,射线全身照射后24h，小鼠脾细胞经ConA刺激48 h，其细胞外液使2 Gy,X,射线全身照射小鼠后体外培养的胸腺细胞凋亡降低，尤其在培养后72 h降低明显（,P,<,0.05）。与此同时，脾细胞CD 25表达（,P,<,0.01）及IFN-γ分泌（,P,<,0.05）明显增高。上述结果提示，小剂量辐射改变了免疫器官的微环境及其信息传递过程，使免疫功能增强，细胞成熟和分化加速，凋亡降低。

Abstract

The splenocytes were cultured with ConA for 48 h in vitro 24 h after whole-body irradiation (WBI) with 75mGy X-rays in mice. The extracellular fluid of the splenocytes decreased the thymocyte apoptosis in vitro 24 h after WBI with 2Gy X-rays in mice, especially decreased significantly 72 h after the thymocyte culture (,P,<,0.05). Meantime, the CD 25 (IL-2 recepter) expression of the splenocytes (,P,<,0.01) and its IFN-γ secretion (,P,<,0.05) enhanced significantly. The results suggest that low dose radiation changes the microenvironment of immune organs and the process of their informention transfer to lead to the enhancement of immune functions, the acceleration of the maturation and differentiation of immune cells and reduction of their apoptosis.

关键词

小剂量照射脾细胞外液胸腺细胞细胞凋亡

Keywords

Low dose radiationSplenocyte extracellular fluidThymocytesApoptosis

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