MECHANISM OF SUPPRESSIVE EFFECT OF LOW DOSE RADIATION ON CANCER CELL DISSEMINATION IN MICE

Fu Haiqing; Li Xiuyi; Chen Yubing; Zhang Yingchun; Liu Shuzheng

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MECHANISM OF SUPPRESSIVE EFFECT OF LOW DOSE RADIATION ON CANCER CELL DISSEMINATION IN MICE

更新时间：2023-04-23

- MECHANISM OF SUPPRESSIVE EFFECT OF LOW DOSE RADIATION ON CANCER CELL DISSEMINATION IN MICE
- Journal of Radiation Research and Radiation Processing Vol. 15, Issue 1, Pages: 40-43(1997)
- 作者机构：
  
  1.白求恩医科大学卫生部放射生物重点实验室　长春　130021
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Fu Haiqing, Li Xiuyi, Chen Yubing, et al. MECHANISM OF SUPPRESSIVE EFFECT OF LOW DOSE RADIATION ON CANCER CELL DISSEMINATION IN MICE. [J]. Journal of Radiation Research and Radiation Processing 15(1):40-43(1997)
DOI：

Fu Haiqing, Li Xiuyi, Chen Yubing, et al. MECHANISM OF SUPPRESSIVE EFFECT OF LOW DOSE RADIATION ON CANCER CELL DISSEMINATION IN MICE. [J]. Journal of Radiation Research and Radiation Processing 15(1):40-43(1997) DOI：

摘要

观察了静脉注入肿瘤细胞前24 h，75 mGy ,X,射线全身照射对小鼠免疫功能的影响。结果表明照射组小鼠胸腺S期细胞百分数于照射后4d，胸腺CD 3,+,细胞百分数于照射后2、8d，脾细胞IL-2和γIFN分泌于照射后4 d，脾脏NK细胞活性于照射后2、4、6和8 d均较假照射组明显增高（,p,<, 0.05～0.01）。提示小剂量辐射增强机体免疫功能可能与其抑制肿瘤细胞播散有关。

Abstract

In this paper, influence of low dose radiation on immunity in C 57 BL/6 mice injected with cancer cells was studied. In mice given 75 mGy WBI 24 h before injection of Lewis lung carcinoma cells or B,16, melonoma cells, the percentage of S-phase thymocytes and CD,3+, thymocytes, the splenic NK cell activity, IL-2 secretion and γIFN secretion were found to be potentiated 2~8 day after irradiation in comparision with the sham-irradiation mice. The results suggest that low dose radiation might suppress cancer cell dissemination via the enhancement of immune reactivity.

关键词

小剂量辐射肿瘤细胞播散NK细胞活性IL-2分泌γIFN分泌

Keywords

Low dose radiationTumor cell disseminationNK cell activityIL-2 secretionγIFN secretion

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