DIRECT CHARACTERIZATION SITE-SELECTIVE PHOTOSENSITIZED DAMAGE OF DNA BY TRIPLET ACETONE

Song Qinhua; Yao Side; Lin Nianyun

您当前的位置：

首页 >

文章列表页 >

DIRECT CHARACTERIZATION SITE-SELECTIVE PHOTOSENSITIZED DAMAGE OF DNA BY TRIPLET ACETONE

更新时间：2023-04-23

- DIRECT CHARACTERIZATION SITE-SELECTIVE PHOTOSENSITIZED DAMAGE OF DNA BY TRIPLET ACETONE
- Journal of Radiation Research and Radiation Processing Vol. 15, Issue 1, Pages: 51-52(1997)
- 作者机构：
  
  1.中国科学院辐射化学开放研究实验室　上海原子核研究所　上海　201800
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
Song Qinhua, Yao Side, Lin Nianyun. DIRECT CHARACTERIZATION SITE-SELECTIVE PHOTOSENSITIZED DAMAGE OF DNA BY TRIPLET ACETONE. [J]. Journal of Radiation Research and Radiation Processing 15(1):51-52(1997)
DOI：

Song Qinhua, Yao Side, Lin Nianyun. DIRECT CHARACTERIZATION SITE-SELECTIVE PHOTOSENSITIZED DAMAGE OF DNA BY TRIPLET ACETONE. [J]. Journal of Radiation Research and Radiation Processing 15(1):51-52(1997) DOI：

摘要

利用纳秒级激光光解动态吸收光谱装置研究了多聚核苷酸及DNA水溶液中光敏化结果：首次观察到丙酮激发三重态分别与多聚鸟苷酸（Poly[G]）、多聚腺-鸟苷酸（Poly[A,G]）及单链DNA（ssDNA）反应生成鸟嘌呤抽氢自由基的瞬态吸收光谱，从而为丙酮三重态对DNA的定位损伤提供了直接证据。

Abstract

The interaction of triplet acetone with polyguanylic acid(Poly[G]). polyadenylic-guanylic acid(Poly[A,G])and single-stranded(ssDNA) were investigated in neutral aqueous solution using KrF (248 nm) laser flash photolysis. The characterized absorption spectra of transient species were observed for the first time. On the basis of a comparison of the transient absorption spectra of the dehydrogenated radical of dGMP and those of Poly[G], Poly[A,G] or ssDNA, we suggest that the photosensitized transient species are guanyl radicals. Therefore, site-selective photosensitized damage of DNA at the guanine moiety was characterized.

关键词

DNA激光光解丙酮三重态鸟嘌呤抽氢自由基定位损伤

Keywords

DNALaser flash photolysisTriplet acetoneGuanyl radicalSite-selective damage

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

A TIME-RESOLVED STUDY ON THE PHOTODYNAMIC PRIMARY PROCESS OF ADE: II. PHOTOCHEMISTRY IN BIOMOLECULAR COMPLEXES

DIRECT OBSERVATION OF SITE—SELECTIVE DAMAGE OF DNA BY FLAVIN PHOTONUCLEASE

DYNAMIC STUDY ON TRIPLET ACETONE INDUCED INTRAMOLECULAR ELECTRON TRANSFER IN PEPTIDE CONTAINING TRYPTOPHAN AND TYROSINE

Clustered DNA damages induced by low-energy (1~20 eV) electrons and the general mechanism of transient anions

Review of domestic radiation biology research

Related Author

No data

Related Institution

Shanghai Institute of Materia Medica, the Chinese Academy of Science

Laboratory of Radiation Chemistry, Shanghai Institute of Nuclear Research, the Chinese Academy of Science

Laboratory of Radiation Chemistry, Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences

Department of Chemical Physics, University of Science and Technology of China

Laboratory of Radiation Chemistry, Shanghai Institute of Nuclear research, Chinese Academy of Sciences

⁰