COMPARISON BETWEEN CHARACTERS OF PHOTOSENSITIZATION AND DARK REACTION OF HYPERICIN AND HYPOCRELLIN A

Zhao Hongxia; Zhang Hongyu; Zhang Zhiyi; Li Meifen

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COMPARISON BETWEEN CHARACTERS OF PHOTOSENSITIZATION AND DARK REACTION OF HYPERICIN AND HYPOCRELLIN A

更新时间：2023-04-23

- COMPARISON BETWEEN CHARACTERS OF PHOTOSENSITIZATION AND DARK REACTION OF HYPERICIN AND HYPOCRELLIN A
- Journal of Radiation Research and Radiation Processing Vol. 15, Issue 3, Pages: 149-154(1997)
- 作者机构：
  
  1.中国科学院生物物理所　北京　100101
- 作者简介：
  
  1The whom correspondence should be addressed
- 基金信息：
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Zhao Hongxia, Zhang Hongyu, Zhang Zhiyi, et al. COMPARISON BETWEEN CHARACTERS OF PHOTOSENSITIZATION AND DARK REACTION OF HYPERICIN AND HYPOCRELLIN A. [J]. Journal of Radiation Research and Radiation Processing 15(3):149-154(1997)
DOI：

Zhao Hongxia, Zhang Hongyu, Zhang Zhiyi, et al. COMPARISON BETWEEN CHARACTERS OF PHOTOSENSITIZATION AND DARK REACTION OF HYPERICIN AND HYPOCRELLIN A. [J]. Journal of Radiation Research and Radiation Processing 15(3):149-154(1997) DOI：

摘要

在DMSO均相体系中研究了金丝桃蒽酮（HYP）光敏作用及暗反应的特征，测得HYP产生,1,O,2,与产生,•,OH的速率常数之比为0.057,产生,1,O,2,与产生HYP,•-,的速率常数之比为1.25,发现HYP在以半胱氨酸为还原剂的条件下，通过热化学作用即可产生O,2,•-,，但O,2,•-产额低于竹红菌甲素（HA）。在TX-100胶束非均相体系中，比较了HYP与HA光敏产生,1,O,2,、,•,OH的产额，发现它们,1,O,2,产额相近，而HYP的,•,OH产额高于HA。

Abstract

Characteristics of photosensitization and dark reaction of hypericin (HYP) are studied in DMSO homogeneous system. Rate constant ratio of HYP of generating O,2,1, to O,2,·-, isdetermined as 0.057 and rate constant ratio of generating O,2,1, to anionradical of HYP (HYP,·-,) is determined as 1.25. It is also found that in existence of cysteine,HYP produce O,2,·-, through thermochemica reaction,but the amount of ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42651273&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42651275&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42651274&type=, is lower than that produced by HA. In TX-100 micellarheterogeneous system,amounts of produced ,1,O,2, and ,•,OH through photosensitization of HYP and HA are compared and it is found that the amount of generated ,1,O,2, is similar to each other,but amount of produced OH of HYP is higher than that of HA.

关键词

金丝桃蒽酮竹红菌甲素活性氧自由基自旋捕捉ESR光敏作用暗反应

Keywords

HypericinHypopcrellin AActive oxygen free radicalSpin trappingESRPhotosensitizationDark reaction

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