MOLECULAR MECHANISM OF DNA pol β IN DNA REPAIR

Zheng Xiulong; Cai Jianming

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MOLECULAR MECHANISM OF DNA pol β IN DNA REPAIR

更新时间：2023-04-23

- MOLECULAR MECHANISM OF DNA pol β IN DNA REPAIR
- Journal of Radiation Research and Radiation Processing Vol. 15, Issue 3, Pages: 168-170,174(1997)
- 作者机构：
  
  1.上海第二军医大学放射医学研究所　上海　200433
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Zheng Xiulong, Cai Jianming. MOLECULAR MECHANISM OF DNA pol β IN DNA REPAIR. [J]. Journal of Radiation Research and Radiation Processing 15(3):168-170,174(1997)
DOI：

Zheng Xiulong, Cai Jianming. MOLECULAR MECHANISM OF DNA pol β IN DNA REPAIR. [J]. Journal of Radiation Research and Radiation Processing 15(3):168-170,174(1997) DOI：

摘要

利用肝癌与正常肝细胞DNA pol β（β酶）活力存在的差别，观察到γ射线照射对β酶活力无明显影响，肝癌细胞的β酶活力仍明显高于正常肝细胞，表明肝癌对照射DNA损伤修复合成能力比正常强，其修复作用机制，经用免疫组化和胞浆斑点杂交法研究，显示肝癌细胞β酶活力的增高是由于基因过度表达及其转录（mRNA）水平的增强有关。

Abstract

The difference of DNA pol βactivity between hepatoma and hepatocytes was used to observe no obvious influence on their activity after γ-irradiation. The pol βactivity of hepatoma was still greater than normal hepatocytes It showed that the repair synthesis ability to the iradiated DNA damage in hepatoma was greater than normal. It was found that the molecular mechanism of pol βwas that higher pol βactivity in hepatoma was due to its gene over expression and higher transcription (mRNA) level by immunocytochemistry and cytoplasmic dot hybridization investigation.

关键词

pol βDNA修复基因表达mRNA

Keywords

pol βDNA repairGene expressionmRNA

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