ENHANCED ANTITUMOR EFFECT AND MECHANISM OF CHEMOTHERAPY COMBINED WITH LOW DOSE RADIATION

Zhang Ying; Liu Shuzheng

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ENHANCED ANTITUMOR EFFECT AND MECHANISM OF CHEMOTHERAPY COMBINED WITH LOW DOSE RADIATION

更新时间：2023-04-23

- ENHANCED ANTITUMOR EFFECT AND MECHANISM OF CHEMOTHERAPY COMBINED WITH LOW DOSE RADIATION
- Journal of Radiation Research and Radiation Processing Vol. 15, Issue 3, Pages: 179-182,178(1997)
- 作者机构：
  
  1.白求恩医科大学卫生部放射生物重点实验室　长春　130021
- 作者简介：
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Zhang Ying, Liu Shuzheng. ENHANCED ANTITUMOR EFFECT AND MECHANISM OF CHEMOTHERAPY COMBINED WITH LOW DOSE RADIATION. [J]. Journal of Radiation Research and Radiation Processing 15(3):179-182,178(1997)
DOI：

Zhang Ying, Liu Shuzheng. ENHANCED ANTITUMOR EFFECT AND MECHANISM OF CHEMOTHERAPY COMBINED WITH LOW DOSE RADIATION. [J]. Journal of Radiation Research and Radiation Processing 15(3):179-182,178(1997) DOI：

摘要

在丝裂霉素C（MMC）或环磷酰胺（CP）腹腔注射前6h，给予荷有Lewis肺癌的C57BL/6小鼠75 mGy X射线全身照射（WBI）。结果表明75mGyX射线全身照射可增强化疗药物的抑瘤作用，肿瘤生长速度明显减慢。同时对与肿瘤免疫相关的某些免疫学指标进行了观察，发现75 mGy X射线全身照射可以促进荷瘤鼠的胸腺和脾细胞的增殖，促进自然杀伤细胞（NK）、淋巴因子激活的杀伤细胞（LAK）和特异性杀伤性T细胞（CTL）的杀伤功能，增加脾细胞白细胞介素Ⅱ（IL-2）的分泌量，并且减低MMC和CP对免疫功能的损害。

Abstract

It is well known that whole body irradiation (WBI) with low dose X-rays could improve the function of the immunological system and the antitumor efficacy of local large dose irradiation. In order to study the adjuvant effect of WBI with low dose on the tumor suppressive effect of chemotherapy, 6 hours before mitomycin C or cyclophosphamide I P administration,WBI with 75 mGy was given to C57BL/6 mice bearing Lewis Lung carcinoma It was found that WBI with 75 mGy X-rays could markedly enhance the suppressive effect of chemotherapy on tumor and significantly increase some immunological parameters related to tumor killing. The results suggested that WBI with 75 mGy X-rays could reduce the immunological damage of tumor-bearing mice caused by chemotherapy and enhance the antitumor efficacy ofcytotoxic agents.

关键词

小剂量辐射Lewis肺癌化疗抑瘤作用

Keywords

Low dose radiationAntitumor effectLewis lungcarcinomaChemotherapy

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