Resveratrol inhibits the radiation-induced expression of inflammatory factor IL-6

WANG Lu; XU Chang; WANG Yan; DU Liqing; WANG Qin; LI Qing; LIU Qiang

doi:10.11889/j.1000-3436.2015.rrj.33.050201

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Resveratrol inhibits the radiation-induced expression of inflammatory factor IL-6

更新时间：2022-09-27

- Resveratrol inhibits the radiation-induced expression of inflammatory factor IL-6
- Journal of Radiation Research and Radiation Processing Vol. 33, Issue 5, Pages: 50201-050201(2015)
- 作者机构：
  
  1. 北京协和医学院中国医学科学院放射医学研究所
- 作者简介：
- 基金信息：
- DOI：10.11889/j.1000-3436.2015.rrj.33.050201
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WANG Lu, XU Chang, WANG Yan, et al. Resveratrol inhibits the radiation-induced expression of inflammatory factor IL-6. [J]. Journal of Radiation Research and Radiation Processing 33(5):50201-050201(2015)
DOI：

WANG Lu, XU Chang, WANG Yan, et al. Resveratrol inhibits the radiation-induced expression of inflammatory factor IL-6. [J]. Journal of Radiation Research and Radiation Processing 33(5):50201-050201(2015) DOI： 10.11889/j.1000-3436.2015.rrj.33.050201.

摘要

探讨白藜芦醇对间充质干细胞（Mesenchymal stem cells,MSCs）电离辐射诱导的炎症因子IL-6的影响,考察白藜芦醇的辐射防护作用。采用不同剂量的电离辐射处理细胞,使用ELISA试剂盒检测IL-6分泌水平,筛选出最适受照剂量4 Gy。用Western-blot和RT-PCR检测辐照后不同时间点IL-6的表达情况,筛选出最适时间点12 h。用不同浓度的白藜芦醇处理MSCs细胞,4 Gy受照后12 h检测IL-6在胞内胞外表达分泌情况。结果表明,电离辐射会引起MSCs的IL-6表达升高,白藜芦醇可以抑制电离辐射诱导IL-6的表达,提示白藜芦醇可以通过抑制电离辐射诱导的炎症因子IL-6的表达发挥辐射防护作用。

Abstract

We aim to investigate the effect of resveratrol on inflammatory factor IL-6 produced in irradiated mesenchymal stem cells（MSCs） and explore the radioprotective effect of resveratrol. MSCs were treated with different concentrations of resveratrol before irradiation, and the expression of IL-6 was detected by ELISA, Western-blot, and RT-PCR. The results showed that ionizing radiation can lead to the increasing of IL-6 expression in MSCs, and resveratrol can inhibit the expression of ionizing radiation-induced IL-6. Resveratrol can inhibit the ionizing radiation-induced expression of inflammatory cytokines IL-6, which suggests that Sirt1 may play a key role in the process of inflammation induced by irradiation.

关键词

白藜芦醇间充质干细胞炎症因子IL-6电离辐射辐射防护

Keywords

ResveratrolMesenchymal stem cells（MSCs）Inflammatory factor IL-6Ionizing radiationRadiation protection

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