Review on molecular mechanisms and protective drugs research on radiation-induced lung fibrosis

Qisheng ZHENG; Peixun LIU

doi:10.11889/j.1000-3436.2016.rrj.34.010101

您当前的位置：

首页 >

文章列表页 >

Review on molecular mechanisms and protective drugs research on radiation-induced lung fibrosis

更新时间：2021-12-10

- Review on molecular mechanisms and protective drugs research on radiation-induced lung fibrosis
- Journal of Radiation Research and Radiation Processing Vol. 34, Issue 1, Pages: 10101(2016)
- 作者机构：
  
  1.北京协和医学院 & 中国医学科学院放射医学研究所天津市放射医学与分子核医学重点实验室天津 300192
  2.Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College & Chinese Academy of Medical Science, Tianjin 300192, China
- 作者简介：
- 基金信息：
- DOI：10.11889/j.1000-3436.2016.rrj.34.010101
  CLC：
扫描看全文
Qisheng ZHENG, Peixun LIU. Review on molecular mechanisms and protective drugs research on radiation-induced lung fibrosis. [J]. Journal of Radiation Research and Radiation Processing 34(1):10101(2016)
DOI：

Qisheng ZHENG, Peixun LIU. Review on molecular mechanisms and protective drugs research on radiation-induced lung fibrosis. [J]. Journal of Radiation Research and Radiation Processing 34(1):10101(2016) DOI： 10.11889/j.1000-3436.2016.rrj.34.010101.

摘要

对放射性肺纤维化(Radiation-induced lung fibrosis,RILF)的发生、发展和最终形成过程中涉及到的细胞、细胞因子、信号通路以及关键因子进行归纳、总结和讨论，并给出具有潜在治疗作用的靶点以及作用在该靶点的相关药物，为今后研发预防与治疗RILF的药物提供思路。

Abstract

The current understanding of the cells, cytokines, and the key factors linked to the signaling networks implicated in RILF were summarized. Targets with potential therapeutic effects for the treatment of RILF were also be discussed and listed. From all above, we hope to provide researchers with ideas in studying the drugs with prevention and (or) the treatment of RILF.

关键词

放射性肺纤维化分子机制细胞因子防护药物综述

Keywords

Radiation-induced lung fibrosis(RILF)Molecular mechanismsCytokinesProtective drugsReview

references

尹勇 , 于金明 , 邢力刚 . 剂量体积直方图参数评估放射性肺损伤的作用 . 中华肿瘤杂志 , 2003 . 25 (04 ):1 -3. .

YIN Yong , YU Jinming , XING Ligang . The role of dose volume histogram parameters to assess radiation-induced lung injury . Chinese Journal of Oncology , 2003 . 25 (04 ):1 -3. .

Straub J M , New J , Hamilton C D , 等 . Radiation-induced fibrosis: mechanisms and implications for therapy . Journal of Cancer Research and Clinical Oncology , 2015 . 141 (11 ):1985 -1994. .

Ghafoori P , Marks L B , Vujaskovic Z , 等 . Radiation-induced lung injury: assessment, management, and prevention . Oncology , 2008 . 22 (1 ):37 -47. .

Zhao W , Robbins M E . Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications . Current Medicinal Chemistry , 2009 . 16 (2 ):130 -143. .

Trott K R , Herrmann T , Kasper M . Target cells in radiation pneumopathy . International Journal of Radiation Oncology Biology Physics , 2004 . 58 (2 ):463 -469. .

Sica A , Mantovani A . Macrophage plasticity and polarization: in vivo veritas . Journal of Clinical Investigation , 2012 . 122 (3 ):787 -795. .

Varin A , Gordon S . Alternative activation of macrophages: immune function and cellular biology . Immunobiology , 2009 . 214 (7 ):630 -641. .

Gordon S , Martinez F O . Alternative activation of macrophages: mechanism and functions . Immunity , 2010 . 32 (5 ):593 -604. .

Zhang H , Han G , Liu H , 等 . The development of classically and alternatively activated macrophages has different effects on the varied stages of radiation-induced pulmonary injury in mice . Journal of Radiation Research , 2011 . 52 (6 ):717 -726. .

Yang K , Palm J , Konig J , 等 . Matrix-Metallo- Proteinases and their tissue inhibitors in radiation-induced lung injury . International Journal of Radiation Biology , 2007 . 83 (10 ):665 -676. .

Quan T E , Cowper S E , Bucala R . The role of circulating fibrocytes in fibrosis . Current Rheumatology Reports , 2006 . 8 (2 ):145 -150. .

Epperly M W , Guo H , Gretton J E , 等 . Bone marrow origin of myofibroblasts in irradiation pulmonary fibrosis . American Journal of Respiratory Cell and Molecular Biology , 2003 . 29 (2 ):213 -224. .

Zeisberg E M , Tarnavski O , Zeisberg M , 等 . Endothelial-to-mesenchymal transition contributes to cardiac fibrosis . Nature Medicine , 2007 . 13 (8 ):952 -961. .

Willis B C , DuBois R M , Borok Z . Epithelial origin of myofibroblasts during fibrosis in the lung . Proceedings of the American Thoracic Society , 2006 . 3 (4 ):377 -382. .

Zavadil J , Bottinger E P . TGF-beta and epithelial-to- mesenchymal transitions . Oncogene , 2005 . 24 (37 ):5764 -5774. .

Kim K K , Kugler M C , Wolters P J , 等 . Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix . Proceedings of the National Academy of Sciences of the United States of America , 2006 . 103 (35 ):13180 -13185. .

Marmai C , Sutherland R E , Kim K K , 等 . Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis . American Journal of Physiology-Lung Cellular and Molecular Physiology , 2011 . 301 (1): .

Tanjore H , Xu X C , Polosukhin V V , 等 . Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis . American Journal of Respiratory and Critical Care Medicine , 2009 . 180 (7 ):657 -665. .

Kalluri R , Neilson E G . Epithelial-mesenchymal transition and its implications for fibrosis . Journal of Clinical Investigation , 2003 . 112 (12 ):1776 -1784. .

Derynck R , Zhang Y E . Smad-dependent and Smad-independent pathways in TGF-beta family signaling . Nature , 2003 . 425 (6958 ):577 -584. .

Balli D , Ustiyan V , Zhang Y , 等 . Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition . Embo Journal , 2013 . 32 (2 ):231 -244. .

Dennler S , Itoh S , Vivien D , 等 . Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene . Embo Journal , 1998 . 17 (11 ):3091 -3100. .

Massague J , Seoane J , Wotton D . Smad transcription factors . Genes & Development , 2005 . 19 (23 ):2783 -2810. .

Masszi A , Di Ciano C , Sirokmany G , 等 . Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition . American Journal of Physiology-Renal Physiology , 2003 . 284 (5): .

Monceau V , Pasinetti N , Schupp C , 等 . Modulation of the Rho/ROCK pathway in heart and lung after thorax irradiation reveals targets to improve normal tissue toxicity . Current Drug Targets , 2010 . 11 (11 ):1395 -1404. .

Zavadil J , Bottinger E P . TGF-beta and epithelial-to- mesenchymal transitions . Oncogene , 2005 . 24 (37 ):5764 -5774. .

Nagarajan D , Melo T , Deng Z , 等 . ERK/GSK3beta/ snail signaling mediates radiation- induced alveolar epithelial-to-mesenchymal transition . Free Radical Biology and Medicine , 2012 . 52 (6 ):983 -992. .

Ghosh S N , Zhang R , Fish B L , 等 . Renin-Angiotensin system suppression mitigates experimental radiation pneumonitis . International Journal of Radiation Oncology Biology Physics , 2009 . 75 (5 ):1528 -1536. .

毛艳 , 刘文其 . 放射性肺损伤防护的研究进展 . 肿瘤 , 2012 . 32 (5 ):389 -394. .

MAO Yan , LIU Wenqi . The progress in the research on the prevention and protection of radiation-induced lung injury . Tumor , 2012 . 32 (5 ):389 -394. .

Travis E L , Parkins C S , Holmes S J , 等 . WR-2721 protection of pneumonitis and fibrosis in mouse lung after single doses of X rays . International Journal of Radiation Oncology Biology Physics , 1984 . 10 (2 ):243 -251. .

Pan J , Su Y , Hou X , 等 . Protective effect of recombinant protein SOD-TAT on radiation-induced lung injury in mice . Life Sciences , 2012 . 91 (3-4 ):89 -93. .

Gauter-Fleckenstein B , Fleckenstein K , Owzar K , 等 . Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage . Free Radical Biology and Medicine , 2010 . 48 (8 ):1034 -1043. .

Terasaki Y , Ohsawa I , Terasaki M , 等 . Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress . American Journal of Physiology-Lung Cellular and Molecular Physiology , 2011 . 301 (4): .

Sekine I , Sumi M , Ito Y , 等 . Retrospective analysis of steroid therapy for radiation-induced lung injury in lung cancer patients . Radiotherapy and Oncology , 2006 . 80 (1 ):93 -97. .

Mathew B , Huang Y , Jacobson J R , 等 . Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression . American Journal of Respiratory Cell and Molecular Biology , 2011 . 44 (3 ):415 -422. .

Puthawala K , Hadjiangelis N , Jacoby S C , 等 . Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation- induced lung fibrosis . American Journal of Respiratory and Critical Care Medicine , 2008 . 177 (1 ):82 -90. .

Hakenjos L , Bamberg M , Rodemann H P . TGF-beta1- mediated alterations of rat lung fibroblast differentiation resulting in the radiation-induced fibrotic phenotype . International Journal of Radiation Biology , 2000 . 76 (4 ):503 -509. .

Anscher M S , Thrasher B , Zgonjanin L , 等 . Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury . International Journal of Radiation Oncology Biology Physics , 2008 . 71 (3 ):829 -837. .

Flechsig P , Dadrich M , Bickelhaupt S , 等 . LY2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of TGF-beta and BMP-associated proinflammatory and proangiogenic signals . Clinical Cancer Research , 2012 . 18 (13 ):3616 -3627. .

Laping N J , Grygielko E , Mathur A , 等 . Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542 . Molecular Pharmacology , 2002 . 62 (1 ):58 -64. .

Li Y , Song L W , Peng R Y , 等 . Effects of SB203580 and WP631 on Smad signal transduction pathway in lung fibroblasts after irradiation . Chinese Journal of Cancer , 2008 . 27 (7 ):698 -702. .

Bao P , Gao W , Li S , 等 . Effect of pretreatment with high-dose ulinastatin in preventing radiation-induced pulmonary injury in rats . European Journal of Pharmacology , 2009 . 603 (1-3 ):114 -119. .

Brickey W J , Neuringer I P , Walton W , 等 . MyD88 provides a protective role in long-term radiation-induced lung injury . International Journal of Radiation Biology , 2012 . 88 (4 ):335 -347. .

Stone M L , Sharma A K , Zhao Y , 等 . Sphingosine- 1-phosphate receptor 1 agonism attenuates lung ischemia- reperfusion injury . American Journal of Physiology- Lung Cellular and Molecular Physiology , 2015 . 308 (12): .

Fujino N , Kubo H , Suzuki T , 等 . Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice . Experimental Lung Research , 2012 . 38 (1 ):28 -36. .

Wang C , Abe S , Matsuda K , 等 . Effects of gefitinib on radiation-induced lung injury in mice . Journal of Nippon Medical School , 2008 . 75 (2 ):96 -105. .

Chen LX , Yang K , Sun M , 等 . Fluorofenidone inhibits transforming growth factor-beta1-induced cardiac myofibroblast differentiation . Pharmazie , 2012 . 67 (5 ):452 -456. .

Przybyszewska M , Miloszewska J , Rzonca S , 等 . Soluble TNF-alpha receptor I encoded on plasmid vector and its application in experimental gene therapy of radiation-induced lung fibrosis . Archivum Immunologiae et Therapiae Experimentalis , 2011 . 59 (4 ):315 -326. .

Bohm L . Inhibition of homologous recombination repair with Pentoxifylline targets G2 cells generated by radio- therapy and induces major enhancements of the toxicity of cisplatin and melphalan given after irradiation . Radiation Oncology , 2006 . 1 12 .

Wand O , Kremer M R . Novel therapies for idiopathic pulmonary fibrosis . Harefuah , 2015 . 154 (7 ):446 -450. .

Li Y , Song L W , Peng R Y , 等 . Effects of SB203580 and WP631 on Smad signal transduction pathway in lung fibroblasts after irradiation . Chinese Journal of Cancer , 2008 . 27 (7 ):698 -702. .

Molteni A , Moulder J E , Cohen E F , 等 . Control of radiation-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin II type 1 receptor blocker . International Journal of Radiation Biology , 2000 . 76 (4 ):523 -532. .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Review of the synthesis of semiconductor nanomaterials using ionizing radiation technology

Review on the ionizing irradiation preparation of semiconductor CdS fluorescent quantum dots

Application of earthworms in the remediation of radioactive soil

Recent progress in irradiation-induced aging of silicones

A review of the relationship of reactive oxygen species with radiation-induced lung injuries

Related Author

No data

Related Institution

Institute of Nuclear Agricultural Science and Space Mutation Breeding, Hunan Academy of Agriculture Sciences

College of Chemistry and Chemical Engineering, Hunan Normal University

College of Resources and Environment, Hunan Agricultural University

School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology

Hubei Key Laboratory of Radiation Chemistry and Functional Materials, Hubei University of Science and Technology

⁰