Electrochemical-based biosensors for quantification microRNA

Fuwu LI; Lihua WANG; Shiping SONG

doi:10.11889/j.1000-3436.2016.rrj.34.030101

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Electrochemical-based biosensors for quantification microRNA

REVIEW | 更新时间：2021-12-10

- Electrochemical-based biosensors for quantification microRNA
- Journal of Radiation Research and Radiation Proces Vol. 34, Issue 3, Pages: 1-11(2016)
- 作者机构：
  
  1.中国科学院上海应用物理研究所嘉定园区上海 201800
- 作者简介：
- 基金信息：
  
  Supported by the National Basic Research Program of China(2012CB932600、2013CB932800)
- DOI：10.11889/j.1000-3436.2016.rrj.34.030101
  CLC：
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Fuwu LI, Lihua WANG, Shiping SONG. Electrochemical-based biosensors for quantification microRNA. [J]. Journal of Radiation Research and Radiation Proces 34(3):1-11(2016)
DOI：

Fuwu LI, Lihua WANG, Shiping SONG. Electrochemical-based biosensors for quantification microRNA. [J]. Journal of Radiation Research and Radiation Proces 34(3):1-11(2016) DOI： 10.11889/j.1000-3436.2016.rrj.34.030101.

摘要

就miRNA电化学法检测中探针材料选择、信号放大方式、电极传感界面调控以及电化学检测方法在研究辐射对miRNA表达的影响方面的潜在应用等方面进行综述。

Abstract

This review outlines the materials of recognition element, methods of signal amplification, interface regulation of electrode and the potential application of the research area in expression level of miRNA influence by radiation.

关键词

MicroRNA癌症生物标记物电化学生物传感器

Keywords

MicroRNACancerBiomarkerElectrochemicalBiosensor

references

W Shen , H M Deng , Y Q Ren , 等 . A label-free microRNA biosensor based on DNAzyme-catalyzed and microRNA-guided formation of a thin insulating polymer film . Biosensors & Bioelectronics , 2013 . 44 171 -176 . DOI:10.1016/j.bios.2013.01.028http://doi.org/10.1016/j.bios.2013.01.028 .

K A Esquela , F J Slack . Oncomirs-microRNAs with a role in cancer . Nature Reviews Cancer , 2006 . 6 (4 ):259 -269 . DOI:10.1038/nrc1840http://doi.org/10.1038/nrc1840 .

D P Bartel . MicroRNAs:Target recognition and regulatory functions . Cell , 2009 . 136 (2 ):215 -233 . DOI:10.1016/j.cell.2009.01.002http://doi.org/10.1016/j.cell.2009.01.002 .

R C Lee , R L Feinbaum , V Ambros . The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 . Cell , 1993 . 75 (5 ):843 -854 . DOI:10.1016/0092-8674(93)90529-Yhttp://doi.org/10.1016/0092-8674(93)90529-Y .

Y Lee , C Ahn , J. Han , 等 . The nuclear RNase III Drosha initiates microRNA processing . Nature , 2003 . 425 (6956 ):415 -419 . DOI:10.1038/nature01957http://doi.org/10.1038/nature01957 .

W Filipowicz , S N Bhattacharyya , N Sonenberg . Mechanisms of post-transcriptional regulation by microRNAs:are the answers in sight? . Nature Reviews Genetics , 2008 . 9 (2 ):102 -114 . DOI:10.1038/nrg2290http://doi.org/10.1038/nrg2290 .

X Zhou , P Cao , Y Zhu , 等 . Phage-mediated counting by the naked eye of miRNA molecules at attomolar concentrations in a Petri dish . Nature Materials , 2015 . 14 (10 ):1058 -1064 . DOI:10.1038/nmat4377http://doi.org/10.1038/nmat4377 .

B A Johnson , X Su , M D Giraldez , 等 . Kinetic fingerprinting to identify and count single nucleic acids . Nature Biotechnology , 2015 . 33 (7 ):730 -732 . DOI:10.1038/nbt.3246http://doi.org/10.1038/nbt.3246 .

YL Wwn , H Pei , Y Shen , 等 . DNA nanostructure-based interfacial engineering for PCR-free ultrasensitive electrochemical analysis of microRNA . Scientific reports , 2012 . 2 867 DOI:10.1038/srep00867http://doi.org/10.1038/srep00867 .

H S Yin , Y L Zhou , C X Chen , 等 . An electrochemical signal ‘off-on’ sensing platform for microRNA detection . The Analyst , 2012 . 137 (6 ):1389 -1395 . DOI:10.1039/c2an16098fhttp://doi.org/10.1039/c2an16098f .

Z L Ge , M H Lin , Ping WANG , 等 . Hybridization chain reaction amplification of microrna detection with a tetrahedral DNA nanostructure-based electrochemical biosensor . Analytical Chemistry , 2014 . 86 (4 ):2124 -2130 . DOI:10.1021/ac4037262http://doi.org/10.1021/ac4037262 .

M H Lin , Y L Wen , L Y Li , 等 . Target-responsive, DNA nanostructure-based e-DNA sensor for microRNA analysis . Analytical Chemistry , 2014 . 86 (5 ):2285 -2288 . DOI:10.1021/ac500251thttp://doi.org/10.1021/ac500251t .

L F Sempere , S Freemantle , R I Pitha , 等 . Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation . Genome Biology , 2004 . 5 (3 ):R13 DOI:10.1186/gb-2004-5-3-r13http://doi.org/10.1186/gb-2004-5-3-r13 .

Y Q Ren , H M Deng , W Shen , 等 . A highly sensitive and selective electrochemical biosensor for direct detection of microRNAs in serum . Analytical Chemistry , 2013 . 85 (9 ):4784 -4789 . DOI:10.1021/ac400583ehttp://doi.org/10.1021/ac400583e .

Q Wang , R D Li , BC Yin , 等 . Colorimetric detection of sequence-specific microRNA based on duplex-specific nuclease-assisted nanoparticle amplification . Analyst , 2015 . 140 (18 ):6306 -6312 . DOI:10.1039/c5an01350jhttp://doi.org/10.1039/c5an01350j .

B S Roberts , A A Hardigan , M K Kirby , 等 . Blocking of targeted microRNAs from next-generation sequencing libraries . Nucleic Acids Research , 2015 . 43 (21 ):e145 DOI:10.1093/nar/gkv724http://doi.org/10.1093/nar/gkv724 .

S Huang , R M Romero , O K Castell , 等 . High-throughput optical sensing of nucleic acids in a nanopore array . Nat Nanotechnol , 2015 . 10 (11 ):986 -991 . DOI:10.1038/nnano.2015.189http://doi.org/10.1038/nnano.2015.189 .

S Roy , J H Soh , J Y Ying . A microarray platform for detecting disease-specific circulating miRNA in human serum . Biosens Bioelectron , 2016 . 75 238 -246 . DOI:10.1016/j.bios.2015.08.039http://doi.org/10.1016/j.bios.2015.08.039 .

Hao ZHANG , Yu LIU , Jian GAO , 等 . A sensitive SERS detection of miRNA using a label-free multifunctional probe . Chemical Communications , 2015 . 51 (94 ):16836 -16839 . DOI:10.1016/j.bios.2015.08.039http://doi.org/10.1016/j.bios.2015.08.039 .

X Feng , N Gan , H Zhang , 等 . Ratiometric biosensor array for multiplexed detection of microRNAs based on electrochemiluminescence coupled with cyclic voltammetry . Biosens Bioelectron , 2016 . 75 308 -314 . DOI:10.1016/j.bios.2015.08.048http://doi.org/10.1016/j.bios.2015.08.048 .

W Wang , T Kong , D Zhang , 等 . Label-free microRNA detection based on fluorescence quenching of gold nanoparticles with a competitive hybridization . Analytical Chemistry , 2015 . 87 (21 ):10822 -10829 . DOI:10.1021/acs.analchem.5b01930http://doi.org/10.1021/acs.analchem.5b01930 .

L Gergely , E G Róbert . Electrochemical detection of miRNAs . Electroanalysis , 2014 . 26 (6 ):1224 -1235 . DOI:10.1002/elan.201400055http://doi.org/10.1002/elan.201400055 .

P Emil , B Martin . Electrochemistry of nucleic acids . Chemical Reviews , 2012 . 112 (6 ):3427 -3481 . DOI:10.1002/elan.201400055http://doi.org/10.1002/elan.201400055 .

H F Dong , S Jin , HX Ju , 等 . Trace and label-free microRNA detection using oligonucleotide encapsulated silver nanoclusters as probes . Analytical Chemistry , 2012 . 84 (20 ):8670 -8674 . DOI:10.1021/ac301860vhttp://doi.org/10.1021/ac301860v .

YL Wen , H Pei , Y Wan , 等 . DNA nanostructure-decorated surfaces for enhanced aptamertarget binding and electrochemical cocaine sensors . Analytical Chemistry , 2011 . 83 (19 ):7418 -7423 . DOI:10.1021/ac201491phttp://doi.org/10.1021/ac201491p .

J X Wang , X Y Yi , H L Tang , 等 . Direct quantification of microRNA at low picomolar level in sera of glioma patients using a competitive hybridization followed by amplified voltammetric detection . Analytical Chemistry , 2012 . 84 (15 ):6400 -6406 . DOI:10.1021/ac203368hhttp://doi.org/10.1021/ac203368h .

Z Q Gao , Z Yang . Detection of microRNAs using electrocatalytic nanoparticle tags . Analytical Chemistry , 2006 . 78 (5 ):1470 -1477 . DOI:10.1021/ac051726mhttp://doi.org/10.1021/ac051726m .

L Mahmoud , K Nasrin , M Shahrokh , 等 . Three-mode electrochemical sensing of ultralow microrna levels . Journal of the American Chemical Society , 2013 . 135 (8 ):3027 -3038 . DOI:10.1021/ja308216zhttp://doi.org/10.1021/ja308216z .

A Rudolf , M F Bernhard . Single-cell identification in microbial communities by improved fluorescence in situ hybridization techniques . Nature Reviews Microbiology , 2008 . 6 (5 ):339 -348 . DOI:10.1038/nrmicro1888http://doi.org/10.1038/nrmicro1888 .

P E Nielsen , M Egholm , R H Berg , 等 . Sequenceselective recognition of DNA by strand displacement with a thymine-substituted polyamide . Science , 1991 . 254 (5037 ):1497 -1500 . DOI:10.1126/science.1962210http://doi.org/10.1126/science.1962210 .

M Egholm , O Buchardt , L Christensen , 等 . PNA hybridizes to complementary oligonucleotides obeying the watson-crick hydrogen-bonding rules . Nature , 1993 . 365 (6446 ):566 -568 . DOI:10.1038/365566a0http://doi.org/10.1038/365566a0 .

R P Singh , B K Oh , J W Choi . Application of peptide nucleic acid towards development of nanobiosensor arrays . Bioelectrochemistry , 2010 . 79 (2 ):153 -161 . DOI:10.1016/j.bioelechem.2010.02.004http://doi.org/10.1016/j.bioelechem.2010.02.004 .

Y Fan , X T Chen , D T Alastair , 等 . Detection of microRNAs using target-guided formation of conducting polymer nanowires in nanogaps . Journal of the American Chemical Society , 2007 . 129 (17 ):5437 -5443 . DOI:10.1021/ja067477ghttp://doi.org/10.1021/ja067477g .

ZQ Gao . A highly sensitive electrochemical assay for microRNA expression profiling . The Analyst , 2012 . 137 (7 ):1674 -1679 . DOI:10.1039/c2an15974khttp://doi.org/10.1039/c2an15974k .

L A Neely , S Patel , J Garver , 等 . A single-molecule method for the quantitation of microRNA gene expression . Nature Methods , 2006 . 3 (1 ):41 -46 . DOI:10.1038/nmeth825http://doi.org/10.1038/nmeth825 .

J Chen , J Zhang , K Wang , 等 . Electrochemical biosensor for detection of BCR/ABL fusion gene using locked nucleic acids on 4-aminobenzenesulfonic acid-modified glassy carbon electrode . Analytical Chemistry , 2008 . 80 (21 ):8028 -8034 . DOI:10.1021/ac801040ehttp://doi.org/10.1021/ac801040e .

L Wang , C J Yang , C D Medley , 等 . Locked nucleic acid molecular beacons . Journal of the American Chemical Society , 2005 . 127 (45 ):15664 -15665 . DOI:10.1021/ja052498ghttp://doi.org/10.1021/ja052498g .

A Válóczi , C Hornyik , N Varga , 等 . Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes . Nucleic Acids Research , 2004 . 32 (22 ):e175 DOI:10.1093/nar/gnh171http://doi.org/10.1093/nar/gnh171 .

L Z Liu , ST Jiang , L Wang , 等 . Direct detection of microRNA-126 at a femtomolar level using a glassy carbon electrode modified with chitosan, graphene sheets, and a poly (amidoamine) dendrimer composite with gold and silver nanoclusters . Microchimica Acta , 2015 . 182 (1-2 ):77 -84 . DOI:10.1007/s00604-014-1273-yhttp://doi.org/10.1007/s00604-014-1273-y .

H Yin , Y Zhou , H Zhang , 等 . Electrochemical determination of microRNA-21 based on graphene, LNA integrated molecular beacon, AuNPs and biotin multifunctional bio bar codes and enzymatic assay system . Biosensors & Bioelectronics , 2012 . 33 (1 ):247 -253 . DOI:10.1016/j.bios.2012.01.014http://doi.org/10.1016/j.bios.2012.01.014 .

M Labib , M V B Berezovski . Electrochemical sensing of microRNAs:Avenues and paradigms . Biosensors & Bioelectronics , 2015 . 68 83 -94 . DOI:10.1016/j.bios.2014.12.026http://doi.org/10.1016/j.bios.2014.12.026 .

C H Fan , K W Plaxco , A J Heeger . Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA . Proceedings of the National Academy of Sciences of the United States of America , 2003 . 100 (16 ):9134 -9137 . DOI:10.1073/pnas.1633515100http://doi.org/10.1073/pnas.1633515100 .

T Y Wang , V Emilie , M Didier , 等 . Microelectrode miRNA sensors enabled by enzyme less electrochemical signal amplification . Analytical Chemistry , 2015 . 87 (16 ):8173 -8180 . DOI:10.1021/acs.analchem.5b00780http://doi.org/10.1021/acs.analchem.5b00780 .

P H A Rafiee , M Behpour , M Keshavarz . A novel label-free electrochemical miRNA biosensor using methylene blue as redox indicator:application to breast cancer biomarker miRNA-21 . Biosensors & Bioelectronics , 2016 . 77 202 -207 . DOI:10.1016/j.bios.2015.09.025http://doi.org/10.1016/j.bios.2015.09.025 .

H Yang , A Hui , G Pampalakis , 等 . Direct, electronic microRNA detection for the rapid determination of differential expression profiles . Angewandte Chemie-International Edition , 2009 . 48 (45 ):8461 -8464 . DOI:10.1002/anie.200902577http://doi.org/10.1002/anie.200902577 .

X Y Wu , Y Q Chai , P Zhang , 等 . An electrochemical biosensor for sensitive detection of microRNA-155:combining target recycling with cascade catalysis for signal amplification . Acs Applied Materials & Interfaces , 2015 . 7 (1 ):713 -720 . DOI:10.1021/am507059nhttp://doi.org/10.1021/am507059n .

X Y Ouyang , J Li , H J Liu , 等 . Rolling circle amplification-based DNA origami nanostructrures for intracellular delivery of immunos-timulatory drugs . Small , 2013 . 9 (18 ):3082 -3087 . DOI:10.1002/smll.201300458http://doi.org/10.1002/smll.201300458 .

K Shi , B T Dou , C Y Yang , 等 . DNA-fueled molecular machine enables enzyme-free target recycling amplification for electronic detection of microRNA from cancer cells with highly minimized background noise . Analytical Chemistry , 2015 . 87 (16 ):8578 -8583 . DOI:10.1021/acs.analchem.5b02418http://doi.org/10.1021/acs.analchem.5b02418 .

J Yan , C Hu , P Wang , 等 . Growth and origami folding of DNA on nanoparticles for high-efficiency molecular transport in cellular imaging and drug delivery . Angewandte Chemie-International Edition , 2015 . 54 (8 ):2431 -2435 . DOI:10.1002/anie.201408247http://doi.org/10.1002/anie.201408247 .

Q Q Tian , Y Wang , R J Deng , 等 . Carbon nanotube enhanced label-free detection of microRNAs based on hairpin probe triggered solid-phase rolling-circle amplification . Nanoscale , 2015 . 7 987 -993 . DOI:10.1039/c4nr05243ahttp://doi.org/10.1039/c4nr05243a .

P Miao , B D Wang , F Y Meng , 等 . Ultrasensitive detection of microRNA through rolling circle amplification on a DNA tetrahedron decorated electrode . Bioconjugate Chemistry , 2015 . 26 (3 ):602 -607 . DOI:10.1021/acs.bioconjchem.5b00064http://doi.org/10.1021/acs.bioconjchem.5b00064 .

Z Q Gao , Z C Yang . Detection of microRNAs using electrocatalytic nanoparticle tags . Analytical Chemistry , 2006 . 78 (5 ):1470 -1477 . DOI:10.1021/ac051726mhttp://doi.org/10.1021/ac051726m .

T Kilic , S N Topkaya , A D Ozkan , 等 . Electrochemical based detection of microRNA, mir21 in breast cancer cells . Biosensors & Bioelectronics , 2012 . 38 (1 ):195 -201 . DOI:10.1016/j.bios.2012.05.031http://doi.org/10.1016/j.bios.2012.05.031 .

C Y Hong , X Chen , T Liu , 等 . Ultrasensitive electrochemical detection of cancer-associated circulating microRNA in serum samples based on DNA concatamers . Biosensors & Bioelectronics , 2013 . 50 132 -136 . DOI:10.1016/j.bios.2013.06.040http://doi.org/10.1016/j.bios.2013.06.040 .

H V Tran , B Piro , S Reisberg , 等 . Antibodies directed to RNA/DNA hybrids:an electrochemical immunosensor for microRNAs detection using graphene-composite electrodes . Analytical Chemistry , 2013 . 85 (17 ):8469 -8474 . DOI:10.1021/ac402154zhttp://doi.org/10.1021/ac402154z .

H V Tran , B Piro , S Reisberg , 等 . Label-free and reagentless electrochemical detection of microRNAs using a conducting polymer nanostructured by carbon nanotubes:application to prostate cancer biomarker miR-141 . Biosensors & Bioelectronics , 2013 . 49 164 -169 . DOI:10.1016/j.bios.2013.05.007http://doi.org/10.1016/j.bios.2013.05.007 .

M Bartosik , R Hrstka , E Palecek , 等 . Magnetic bead-based hybridization assay for electrochemical detection of microRNA . Analytica Chimica Acta , 2014 . 813 35 -40 . DOI:10.1016/j.aca.2014.01.023http://doi.org/10.1016/j.aca.2014.01.023 .

F Li , J Peng , J Wang , 等 . Carbon nanotube-based label-free electrochemical biosensor for sensitive detection of miRNA-24 . Biosensors & Bioelectronics , 2014 . 54 158 -164 . DOI:10.1016/j.bios.2013.10.061http://doi.org/10.1016/j.bios.2013.10.061 .

N Xia , L Zhang , G Wang , 等 . Label-free and sensitive strategy for microRNAs detection based on the formation of boronate ester bonds and the dual-amplification of gold nanoparticles . Biosensors & Bioelectronics , 2013 . 47 461 -466 . DOI:10.1016/j.bios.2013.03.074http://doi.org/10.1016/j.bios.2013.03.074 .

Z Wang , J Zhang , Y Guo , 等 . A novel electrically magnetic-controllable electrochemical biosensor for the ultra sensitive and specific detection of attomolar level oral cancer-related microRNA . Biosensors & Bioelectronics , 2013 . 45 108 -113 . DOI:10.1016/j.bios.2013.02.007http://doi.org/10.1016/j.bios.2013.02.007 .

Y F Peng , Z Q Gao . Amplified detection of microRNA based on ruthenium oxide nanoparticle-initiated deposition of an insulating film . Analytical Chemistry , 2011 . 83 (3 ):820 -827 . DOI:10.1021/ac102370shttp://doi.org/10.1021/ac102370s .

P Christopher , S S Mathias . Electrochemical detection of microRNAs via gap hybridization assay . Analytical Chemistry , 2010 . 82 (11 ):4434 -4440 . DOI:10.1021/ac100186phttp://doi.org/10.1021/ac100186p .

L Rastislav , M H Tonya , J T Michael , 等 . Using self-assembly to control the structure of DNA monolayers on gold:A neutron reflectivity study . Journal of the American Chemical Society , 1998 . 120 (38 ):9787 -9792 . DOI:10.1021/ja981897rhttp://doi.org/10.1021/ja981897r .

M Azimzadeh , M Rahaie , N. Nasirizadeh , 等 . An electrochemical nanobiosensor for plasma miRNA-155, based on graphene oxide and gold nanorod, for early detection of breast cancer . Biosens Bioelectron , 2016 . 77 99 -106 . DOI:10.1016/j.bios.2015.09.020http://doi.org/10.1016/j.bios.2015.09.020 .

J Zhang , D Z Wu , S X Cai , 等 . An immobilization-free electrochemical impedance biosensor based on duplexspecific nuclease assisted target recycling for amplified detection of microRNA . Biosensors & Bioelectronics , 2016 . 75 452 -457 . DOI:10.1016/j.bios.2015.09.006http://doi.org/10.1016/j.bios.2015.09.006 .

Mengsu YANG , M E Mcgovern , M Thompson . Genosensor technology and the detection of interfacial nucleic acid Chemistry . Analytica Chimica Acta , 1997 . 346 (3 ):259 -275 . DOI:10.1016/S0003-2670(97)90055-6http://doi.org/10.1016/S0003-2670(97)90055-6 .

H Pei , X L Zuo , D Zhu , 等 . Functional DNA nanostructures for theranostic applications . Accounts of Chemical Research , 2014 . 47 (2 ):550 -559 . DOI:10.1021/ar400195thttp://doi.org/10.1021/ar400195t .

H Pei , Na Lu , Yanli Wen , 等 . A DNA nanostructure-based biomolecular probe carrier platform for electrochemical biosensing . Advanced Materials , 2010 . 22 (42 ):4754 -4758 . DOI:10.1002/adma.201002767http://doi.org/10.1002/adma.201002767 .

Z L Ge , H Pei , LH Wang , 等 . Electrochemical single nucleotide polymorphisms genotyping on surface immobilized three-dimensional branched DNA nanostructure . Science China Chemistry (in China) , 2011 . 54 (8 ):1273 -1276 . DOI:10.1007/s11426-011-4327-6http://doi.org/10.1007/s11426-011-4327-6 .

Y Wen , G Liu , H Pei , 等 . DNA nanostructure-based ultrasensitive electrochemical microRNA biosensor . Methods , 2013 . 64 (3 ):276 -282 . DOI:10.1016/iymeth.2013.07.035http://doi.org/10.1016/iymeth.2013.07.035 .

P Miao , B D Wang , X F Chen , 等 . Tetrahedral DNA nanostructure-based microRNA biosensor coupled with catalytic recycling of the analyte . Acs Applied Materials & Interfaces , 2015 . 7 (11 ):6238 -6243 . DOI:10.1021/acsami.5b01508http://doi.org/10.1021/acsami.5b01508 .

王旭丹 , 杨惠玲 , 郭禹标 , 等 . 不同辐射抗拒鼻咽癌细胞微小RNA 差异表达的研究 . 中国病理生理杂质 , 2007 . 23 (6 ):1045 -1048. .

Xudan WANG , Huiling YANG , Yubiao GUO , 等 . Discrepancy of microRNA in different radioresistant nasopharyngeal carcinoma cells . Chinese Journal of Pathophysiology , 2007 . 23 (6 ):1045 -1048. .

F M Cui , XJ Sun , X Ding , 等 . Differential expression profiles of micrornas in mice internally exposed to tritiated water . Toxicological & Environmental Chemistry , 2011 . 93 (4 ):738 -751 . DOI:10.1016/j.toxlet.2010.03.250http://doi.org/10.1016/j.toxlet.2010.03.250 .

肖海楠 , 段广新 , 张燕娟 , 等 . miRNA 对肺腺癌A549 细胞的辐射增敏效应 . 苏州大学学报(医学版) , 2012 . 32 (2 ):157 -160. .

Hainan XIAO , Guangxin DUAN , Yanjuan ZHANG , 等 . The radiation sensitization effect of miRNA-34c on A549 cell . Journal of Soochow University:Medical Science Edition , 2012 . 32 (2 ):157 -160. .

K Tjensvoll , O Nordgård , R Smaaland . Circulating tumor cells in pancreatic cancer patients:methods of detection and clinical implications . International Journal of Cancer , 2014 . 134 (1 ):1 -8 . DOI:10.1002/ijc.28134http://doi.org/10.1002/ijc.28134 .

U Halm , T Schumann , I Schiefke , 等 . Decrease of CA 19-9 during chemotherapy with gemcitabine predicts survival time in patients with advanced pancreatic cancer . British Journal of Cancer , 2000 . 82 (5 ):1013 -1016 . DOI:10.1054/bjoc.1999.1035http://doi.org/10.1054/bjoc.1999.1035 .

P L Mark . Cancer after exposure to radiation in the course of treatment for benign and malignant disease . The Lancet Oncology , 2001 . 2 (4 ):212 -220 . DOI:10.1016/S1470-2045(00)00291-6http://doi.org/10.1016/S1470-2045(00)00291-6 .

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