Dosimetric comparing four kinds of radiation treatment planning for esophagus cancer

Qili XIONG; Gang XU; Yong SHI; Qianxi NI; Qiang GU

doi:10.11889/j.1000-3436.2016.rrj.34.050201

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Dosimetric comparing four kinds of radiation treatment planning for esophagus cancer

RADIOBIOLOGY AND RADIOMEDICINE | 更新时间：2021-12-10

- Dosimetric comparing four kinds of radiation treatment planning for esophagus cancer
- Journal of Radiation Research and Radiation Processing Vol. 34, Issue 5, (2016)
- 作者机构：
  
  1.中国科学院上海应用物理研究所嘉定园区上海 201800
  2.上海大学上海 200444
  3.中南大学湘雅医学院附属肿瘤医院长沙 410013
  4.中南大学湘雅三医院长沙 410013
- 作者简介：
- 基金信息：
  
  the National Natural Science Foundation(11175112)
- DOI：10.11889/j.1000-3436.2016.rrj.34.050201
  CLC：
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Qili XIONG, Gang XU, Yong SHI, et al. Dosimetric comparing four kinds of radiation treatment planning for esophagus cancer. [J]. Journal of Radiation Research and Radiation Processing 34(5):050201-7(2016)
DOI：

Qili XIONG, Gang XU, Yong SHI, et al. Dosimetric comparing four kinds of radiation treatment planning for esophagus cancer. [J]. Journal of Radiation Research and Radiation Processing 34(5):050201-7(2016) DOI： 10.11889/j.1000-3436.2016.rrj.34.050201.

摘要

比较食管癌患者应用螺旋断层（TomoHelical，TH）、径照断层（TomoDirect，TD）、容积旋转调强（Volumetric modulated arc therapy，VMAT）和固定野动态调强（Intensity modulated radiation therapy，IMRT）4种放疗计划的剂量学差异。选取18例食管癌患者，利用Pinnacle9.2计划系统设计单弧360°VMAT放疗计划和5野IMRT放疗计划。利用TomoHDTM2.0.7计划系统设计TH放疗计划和5野TD放疗计划。利用剂量体积直方图（Dose volume histogram，DVH）统计靶区剂量参数、适形性指数（Conformity index，,CI,）和均匀性指数（Heterogeneity index，,HI,），肺、心脏、脊髓剂量体积参数，出束时间和治疗跳数。TH计划靶区适形性和靶区均匀性略优于TD计划，VMAT计划靶区适形性和靶区均匀性略优于IMRT计划，且前两种计划明显优于后两种；TH计划和VMAT计划肺,V,20Gy,、,V,30Gy,，心脏,V,30Gy,、,V,40Gy,分别优于TD计划和IMRT计划；但是TD计划肺,V,5Gy,具有其他计划都不具有的优势。TH计划优于TD计划优于VMAT计划优于IMRT计划。但如果考虑性价比，本研究认为对于食管癌VMAT计划是首选；如果考虑放射治疗计划的质量，TH计划是首选；但如果靶区体积比较大，肺的低剂量无法达到临床要求时，可以考虑用TD计划解决这一难题。

Abstract

Dose differences among TomoHelical (TH), TomoDirect (TD), Volumetric modulated arc therapy (VMAT) and intensity modulated radiation therapy (IMRT) for esophagus cancer were compared. Eighteen esophageal patients were chosen. The Pinnacle 9.2 treatment planning system was used to generate the VMAT plan and the five field IMRT plan. For comparison, the TH plan and five field TD plan were generated by TomoHDTM 2.0.7 treatment planning system. It was available to adopt the dose volume histograms to investigate the dose parameters of target, the statistics of conformity index (,CI,), the heterogeneity index (,HI,) of planning target volume (PTV), the dose volumetric parameters of lung, and the spinal cord and heart, total accelerator output monitor units and total treatment time. The results showed that the ,CI, and ,HI, of TH plan was better than TD plan, and VMAT plan was better than IMRT plans, and the first two plans were better than the latter two; the lung's ,V,20Gy, and ,V,30Gy, heart's ,V,30Gy, and ,V,40Gy, of TH plan and VMAT plan were better than those of TD plan and IMRT plan. However, the lung's ,V,5Gy, of TD plan had a greater advantage among them. The TH plan was better than TD plan, TD plan was better than VMAT plan, VMAT plan was better than IMRT plan. Taken the cost into consideration, the esophageal VMAT plan is preferred, and considering the therapeutic effect and quality of survival, the TH plan is preferred. When the target volume is relatively large, the low-dose lung is unavailable to achieve the clinical requirements. Therefore it is proposed to use the TD plans to cure the patients. Dose volume histograms are adopted for the statistics of ,CI, HI, of PTV, dose volumetric parameters of lung, spinal cord and heart, total accelerator output monitor units and total treatment time.

关键词

食管癌螺旋断层径照断层容积旋转调强固定野动态调强剂量学比较

Keywords

Esophagus cancerTomoHelicalTomoDirectVolumetric modulated arc therapyIntensity modulated radiation therapyDosimetric comparison

references

L Van Benthuysen , L Hales , M Podgorsak . Volumetric modulated arc therapy vs. IMRT for the treatment of distal esophageal cancer . Medical Dosimetry Official Journal of the American Association of Medical Dosimetrists , 2011 . 36 (4 ):404 -409 . DOI:10.1016/j.meddos.2010.09.009http://doi.org/10.1016/j.meddos.2010.09.009 .

刘晓静 , 张西志 , 李军 , 等 . 胸中段食管癌旋转容积调强与固定野动态调强放疗的剂量学研究 . 实用癌症杂志 , 2011 . 26 (6 ):630 -633 . DOI:10.3969/j.issn.1001-5930.2011.06.025http://doi.org/10.3969/j.issn.1001-5930.2011.06.025 .

Xiaojing LIU , Xizhi ZHANG , Jun LI , 等 . Dosimetric comparison between rapidarc and fixed gantry dynamic IMRT for middle esophageal carcinoma . The Practical Journal of Cancer , 2011 . 26 (6 ):630 -633 . DOI:10.3969/j.issn.1001-5930.2011.06.025http://doi.org/10.3969/j.issn.1001-5930.2011.06.025 .

G Nicolini , S Ghosh-Laskar , S K Shrivastava , 等 . Volumetric modulated arc therapy with flattening filter-free beams compared with static gantry IMRT and 3D conformal radiotherapy for advanced esophageal cancer: a feasibility study . International Journal of Radiation Oncology Biology Physics , 2012 . 84 (2 ):553 -560 . DOI:10.1016/j.ijrobp.2011.12.041http://doi.org/10.1016/j.ijrobp.2011.12.041 .

K Otto . Volumetric modulated arc therapy: IMRT in a single gantry arc . Medical Physics , 2008 . 35 (1 ):310 -317 . DOI:10.1118/1.2818738http://doi.org/10.1118/1.2818738 .

A S Abbas , D Moseley , Z Kassam , 等 . Volumetric-modulated arc therapy for the treatment of a large planning target volume in thoracic esophageal cancer . Journal of Applied Clinical Medical Physics , 2013 . 14 (3 ):1269 DOI:10.1120/jacmp.v14i3.4269http://doi.org/10.1120/jacmp.v14i3.4269 .

M A Hawkins , J L Bedford , A P Warrington , 等 . Volumetric modulated arc therapy planning for distal oesophageal malignancies . British Journal of Radiology , 2012 . 85 (1009 ):44 -52 . DOI:10.1259/bjr/25428720http://doi.org/10.1259/bjr/25428720 .

马林 . 螺旋断层放疗系统的临床应用 . 中国医疗设备 , 2014 . (10 ):12 -14 . DOI:10.3969/j.issn.1674-1633.2014.10.004http://doi.org/10.3969/j.issn.1674-1633.2014.10.004 .

Lin MA . Clinical Application of Tomotherapy System . China medical devices , 2014 . (10 ):12 -14 . DOI:10.3969/j.issn.1674-1633.2014.10.004http://doi.org/10.3969/j.issn.1674-1633.2014.10.004 .

P Franco , P Catuzzo , D Cante , 等 . TomoDirect: an efficient means to deliver radiation at static angles with tomotherapy . Tumori , 2011 . 97 (4 ):498 -502 . DOI:10.1700/950.10404http://doi.org/10.1700/950.10404 .

K M Langen , D J Buchholz , D R Burch , 等 . Investigation of accelerated partial breast patient alignment and treatment with helical tomotherapy unit . International Journal of Radiation Oncology biology physics , 2008 . 70 (4 ):1272 -1280 . DOI:10.1016/j.ijrobp.2007.11.019http://doi.org/10.1016/j.ijrobp.2007.11.019 .

T Murai , Y Shibamoto , Y Manabe , 等 . Intensity-modulated radiation therapy using static ports of tomo-therapy (TomoDirect): comparison with the TomoHelical mode . Radiation Oncology , 2013 . 8 (1 ):100 -112 . DOI:10.1186/1748-717X-8-201http://doi.org/10.1186/1748-717X-8-201 .

V C Borca , P Franco , P Catuzzo , 等 . Does TomoDirect 3DCRT represent a suitable option for post-operative whole breast irradiation? A hypothesis-generating pilot study . Radiation Oncology , 2012 . 7 (1 ):1 -10 . DOI:10.1186/1748-717X-7-211http://doi.org/10.1186/1748-717X-7-211 .

International Commission on Radiation Units and Measurements (ICRU)(2010) . Prescribing, recording, and reporting photon beam intensity-modulated radiation therapy (IMRT) . Journal of the ICRU , 2012 . 10 (1 ):26 -29 . DOI:10.1093/jicru/ndq002http://doi.org/10.1093/jicru/ndq002 .

N Vivekanandan , P Sriram , S A Kumar , 等 . Volumetric modulated arc radiotherapy for esophageal cancer . Medical Dosimetry Official Journal of the American Association of Medical Dosimetrists , 2012 . 37 (1 ):108 -113 . DOI:10.1016/j.meddos.2011.01.008http://doi.org/10.1016/j.meddos.2011.01.008 .

Y Yin , J Chen , L Xing , 等 . Applications of IMAT in cervical esophageal cancer radiotherapy: a comparison with fixed field IMRT in dosimetry and implementation . Journal of Applied Clinical Medical Physics , 2011 . 12 (2 ):48 -57 . http://www.ncbi.nlm.nih.gov/pubmed/21587177http://www.ncbi.nlm.nih.gov/pubmed/21587177, .

张瑞 , 习勉 , 李巧巧 , 等 . 胸上段食管癌容积旋转调强和静态调强与三维适形放疗计划的剂量学比较 . 中山大学学报(医学科学版) , 2012 . 33 (2 ):260 -264 . DOI:10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2012.0046http://doi.org/10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2012.0046 .

Rui ZHANG , Mian XI , Qiaoqiao LI , 等 . Volumetric modulated arc therapy, conventional intensity-modulated radiotherapy and three-dimensional conformal techniques for upper thoracic esophageal cancer: a planning comparison study . Journal of Sun Yat-sen University (Medical Sciences) , 2012 . 33 (2 ):260 -264 . DOI:10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2012.0046http://doi.org/10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2012.0046 .

陈进琥 , 尹勇 , 刘同海 , 等 . 颈段食管癌固定野调强与旋转调强放疗计划比较研究 . 中华放射肿瘤学杂志 , 2010 . 19 (5 ):429 -435 . DOI:10.3760/cma.j.issn.1004-4221.2010.05.013http://doi.org/10.3760/cma.j.issn.1004-4221.2010.05.013 .

Jinhu CHEN , Yong YI , Tonghai LIU , 等 . Application of IMAT versus fixed-gantry IMRT in cervical esophageal cancer: a comparison in dosimetry and implementation . Chinese Journal of Radiation Oncology , 2010 . 19 (5 ):429 -435 . DOI:10.3760/cma.j.issn.1004-4221.2010.05.013http://doi.org/10.3760/cma.j.issn.1004-4221.2010.05.013 .

陈婷婷 , 张西志 , 花威 , 等 . 容积旋转调强与固定野动态调强在上段食管癌治疗中的剂量学比较 . 临床肿瘤学杂志 , 2013 . 18 (2 ):151 -154 . DOI:10.3969/j.issn.1009-0460.2013.02.014http://doi.org/10.3969/j.issn.1009-0460.2013.02.014 .

Tingting CHEN , Xizhi ZHANG , Wei HUA , 等 . Dosimetric comparison between rapid arc and fixed gantry dynamic IMRT for upper esophageal cancer . Chinese Clinical Oncology , 2013 . 18 (2 ):151 -154 . DOI:10.3969/j.issn.1009-0460.2013.02.014http://doi.org/10.3969/j.issn.1009-0460.2013.02.014 .

D Palma , E Vollans , K James , 等 . Volumetric modulated arc therapy for delivery of prostate radiotherapy: comparison with intensity-modulated radiotherapy and three-dimensional conformal radiotherapy . International Journal of Radiation Oncology Biology Physics , 2008 . 72 (4 ):996 -1001 . DOI:10.1016/j.ijrobp.2008.02.047http://doi.org/10.1016/j.ijrobp.2008.02.047 .

L B Marks , E D Yorke , A Jackson , 等 . Use of normal tissue complication probability models in the clinic . International Journal of Radiation Oncology Biology Physics , 2010 . 76 (3 ):10 -19 . DOI:10.1016/j.ijrobp.2009.07.1754http://doi.org/10.1016/j.ijrobp.2009.07.1754 .

C S Mayo , M M Urie , T J Fitzgerald , 等 . Hybrid IMRT for treatment of cancers of the lung and esophagus . International Journal of Radiation Oncology Biology Physics , 2008 . 71 (5 ):1408 -1418 . DOI:10.1016/j.ijrobp.2007.12.008http://doi.org/10.1016/j.ijrobp.2007.12.008 .

W H Fu , L H Wang , Z M Zhou , 等 . Comparison of conformal and intensity-modulated techniques for simultaneous integrated boost radiotherapy of upper esophageal carcinoma . World Journal of Gastroenterology , 2004 . 10 (8 ):1098 -1102 . http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZXXY200408004.htmhttp://en.cnki.com.cn/Article_en/CJFDTOTAL-ZXXY200408004.htm, .

G M Cattaneo , I Delloca , S Broggi , 等 . Treatment planning comparison between conformal radiotherapy and helical tomotherapy in the case of locally advanced-stage NSCLC . Radiotherapy and Oncology , 2008 . 88 (5 ):310 -318 . DOI:10.1016/j.radonc.2008.06.006http://doi.org/10.1016/j.radonc.2008.06.006 .

刘清智 , 蒋华勇 , 许卫东 , 等 . 胸膜间皮瘤螺旋断层调强放疗和容积旋转调强放疗的剂量学评估 . 中国医学物理学杂志 , 2015 . 32 (5 ):690 -693 . DOI:10.3969/j.issn.1005-202X.2015.05.017http://doi.org/10.3969/j.issn.1005-202X.2015.05.017 .

Qingzhi LIU , Huayong JIANG , Weidong XU , 等 . Dosimetric evaluation of helical tomotherapy and volumetric-modulated arc therapy for pleural mesothelioma . Chinese Journal of Medical Physics , 2015 . 32 (5 ):690 -693 . DOI:10.3969/j.issn.1005-202X.2015.05.017http://doi.org/10.3969/j.issn.1005-202X.2015.05.017 .

V Murthy , Z Master , T Gupta , 等 . Helical tomotherapy for head and neck squamous cell carcinoma: dosimetric comparison with linear accelerator-based step-and-shoot IMRT . Journal of Cancer Research and Therapeutics , 2012 . 6 (2 ):194 -198 . DOI:10.4103/0973-1482.65245http://doi.org/10.4103/0973-1482.65245 .

A Mcintosh , P W Read , S R Khandelwal , 等 . Evaluation of coplanar partial left breast irradiation using tomotherapy-based topotherapy . International Journal of Radiation Oncology Biology Physics , 2008 . 71 (2 ):603 -610 . DOI:10.1016/j.ijrobp.2008.01.047http://doi.org/10.1016/j.ijrobp.2008.01.047 .

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