Advances of exosome research in cancer radiotherapy and chemotherapy

Junjun LI; Wenzhi TU; Yong LIU

doi:10.11889/j.1000-3436.2017.rrj.35.030102

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Advances of exosome research in cancer radiotherapy and chemotherapy

REVIEW | 更新时间：2021-12-10

- Advances of exosome research in cancer radiotherapy and chemotherapy
- Journal of Radiation Research and Radiation Processing Vol. 35, Issue 3, (2017)
- 作者机构：
  
  1.上海交通大学附属第一人民医院肿瘤中心上海 201620
- 作者简介：
- 基金信息：
  
  the "National Nature Science Foundation of China"(31370838);"National Nature Science Foundation of China"(81602663);"Ministry of Education returned to study fund"(N130204);"Shanghai Municipal Commission of Health and Family Planning"(20164Y0037)
- DOI：10.11889/j.1000-3436.2017.rrj.35.030102
  CLC：
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Junjun LI, Wenzhi TU, Yong LIU. Advances of exosome research in cancer radiotherapy and chemotherapy. [J]. Journal of Radiation Research and Radiation Processing 35(3):030102-8(2017)
DOI：

Junjun LI, Wenzhi TU, Yong LIU. Advances of exosome research in cancer radiotherapy and chemotherapy. [J]. Journal of Radiation Research and Radiation Processing 35(3):030102-8(2017) DOI： 10.11889/j.1000-3436.2017.rrj.35.030102.

摘要

本文就外泌体的提取、富集、追踪及其在放化疗中的应用进展进行综述。目前外泌体提取与富集的主要方法包括超速离心法，层析法和色谱法等，外泌体可通过荧光素酶标记进行追踪。由于外泌体具有特异的表面标志物及其在体液中广泛存在的特点，使其成为潜在的肿瘤标志物之一。此外，外泌体在肿瘤的辐射敏感性与辐射损伤、肿瘤的靶向治疗和多重耐药等放化疗中的作用也日益受到关注。

Abstract

Here, we summarized the isolation, enrichment, and tracking of exosome, as well as its application in radio-and chemotherapy of cancer. Currently, the main extracting methods of exosome include ultracentrifugation, ultrafiltration, and chromatography. Exosome can be tracked by luciferase labeling. Exosome is characterized by specific surface markers and exists in most body fluids, which makes it a potential cancer marker. Moreover, increasing researches have focused on the vital role of exosomes in radiosensitivity, radiation damage, targeted therapy, and multidrug resistance of cancer cells.

关键词

外泌体放疗化疗肿瘤综述

Keywords

ExosomesRadiotherapyChemotherapyCancerReview

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